Is Disodium Phosphate safe in cosmetics?
Disodium Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Disodium Phosphate
Also known as: DISODIUM HYDROGEN PHOSPHATE, Sodium phosphate, dibasic, SODIUM PHOSPHATE, DIBASIC ANHYDROUS, Caswell No. 778, Disodium hydrogen phosphate, anhydrous (+15 more)
INCI: DISODIUM PHOSPHATE
Disodium Phosphate (CAS 7558-79-4) is a cosmetic cosmetic ingredient functioning as Buffering agent, pH adjuster, corrosion inhibitor. NOAEL 145.7 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7558-79-4 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering agent, pH adjuster, corrosion inhibitor
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
disodium;hydrogen phosphate
InChIKey
BNIILDVGGAEEIG-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA classifies sodium phosphate salts as GRAS with no evidence of hazard at current or foreseeable use levels. Also approved as an ingredient in OTC laxative drug products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Causes mild skin irritation Causes eye irritation
Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disodium Phosphate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =17000 mg/kg | Rat | oral | - | ChemIDplus |
| NOAEL | =145.7 mg/kg-day | Human | oral | - | PPRTV (CPHEA) |
| RfD | =1 mg/kg-day | Human | oral | - | RSL |
| RfD | =4 mg/kg-day | Human | oral | - | RSL |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1129
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Dust: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. Solid: Irritating to skin and eyes. | A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
DISODIUM ACID PHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Anti-scaling agent
Biocide
Chelating agent
Corrosion inhibitor
Deodorizer
Drier
Emulsifier
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Phosphate.
Regulatory Flags
buffering-agent
ph-adjuster
fda-gras
cir-safe-2021
inorganic-salt
no-mos-required
eu_children_restricted
fda_food_additive
Known Synonyms
DISODIUM HYDROGEN PHOSPHATE
Sodium phosphate, dibasic
SODIUM PHOSPHATE, DIBASIC ANHYDROUS
Caswell No. 778
Disodium hydrogen phosphate, anhydrous
Disodium phosphate, anhydrous
Disodium phosphoric acid
EINECS 231-448-7
EPA Pesticide Chemical Code 076403
FEMA No. 2398
FEMA Number 2398
Phosphate of soda
secondary Sodium phosphate
Sodium acid phosphate, anhydrous
Sodium hydrogen phosphate
Sodium orthophosphate, secondary
Sodium phosphate, exsiccated
Fleet enema
Natriumphosphat
UNII-22ADO53M6F
Chemical Function
Deodorizer
pH regulating agent
Corrosion inhibitor
Fragrance
Thickening agent
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
children; Europe; Personal care
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - dental care - toothpaste
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS
ChEMBL ID
CHEMBL1060
Max Phase
4
Adverse Event Associations
61
Frequently Asked Questions
Is Disodium Phosphate allowed in the EU?
Disodium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Phosphate do in cosmetics?
Disodium Phosphate functions as: Buffering agent, pH adjuster, corrosion inhibitor. It is classified as a cosmetic ingredient in our database. CAS number: 7558-79-4.
Is Disodium Phosphate classified as hazardous under GHS?
Disodium Phosphate carries a GHS signal word of "WARNING". Hazard statements: Causes mild skin irritation Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Disodium Phosphate used outside cosmetics?
Disodium Phosphate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Disodium Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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