Is Dipotassium Phosphate safe in cosmetics?
Dipotassium Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Dipotassium Phosphate
Also known as: K2HPO4, Dipotassium monohydrogen phosphate, Dipotassium-O-phosphate, EINECS 231-834-5, UNII-CI71S98N1Z (+5 more)
INCI: DIPOTASSIUM PHOSPHATE
Dipotassium Phosphate (CAS 7758-11-4) is a cosmetic cosmetic ingredient functioning as Buffering agent, anticorrosive, pH adjuster. NOAEL 145.7 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7758-11-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dipotassium Phosphate is classified GHS Danger (H315, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering agent, anticorrosive, pH adjuster
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
dipotassium;hydrogen phosphate
InChIKey
ZPWVASYFFYYZEW-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (2021) reviewed phosphoric acid and its salts (31 ingredients) and concluded safe at present use concentrations when formulated to be nonirritating. FDA GRAS status as food additive reinforces low systemic risk.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dipotassium Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dipotassium Phosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
DIPOTASSIUM PHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Corrosion inhibitor
Emulsifier
Flavouring and nutrient
Other
Pharmaceutical
Soil amendments
Thickening agent
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dipotassium Phosphate.
Regulatory Flags
buffering-agent
anticorrosive
inorganic-salt
gras
cir-reviewed
no-concentration-cap
fda_food_additive
Known Synonyms
K2HPO4
Dipotassium monohydrogen phosphate
Dipotassium-O-phosphate
EINECS 231-834-5
UNII-CI71S98N1Z
Hydrogen dipotassium phosphate
Potassium phosphate (dibasic)
Potassium phosphate, dibasic
dipotassium hydrogenphosphate
potassium dibasic phosphate trihydrate
Chemical Function
pH regulating agent
Corrosion inhibitor
Flavouring and nutrient
Regulatory Lists
animal_products
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
POTASSIUM PHOSPHATE, DIBASIC
ChEMBL ID
CHEMBL1200459
Max Phase
4
Adverse Event Associations
20
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Dipotassium diphosphate
E Number
E450iv
ADI
40 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Dipotassium Phosphate allowed in the EU?
Dipotassium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipotassium Phosphate do in cosmetics?
Dipotassium Phosphate functions as: Buffering agent, anticorrosive, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 7758-11-4.
Is Dipotassium Phosphate used outside cosmetics?
Dipotassium Phosphate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dipotassium Phosphate have different safety status in cosmetics vs industrial chemicals?
Dipotassium Phosphate is classified GHS Danger (H315, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dipotassium Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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