What is the NOAEL for Dibasic sodium phosphate?
Dibasic sodium phosphate has 15 NOAEL studies in the database. The lowest reported value is 4.07 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dibasic sodium phosphate
Also known as: DISODIUM HYDROGEN PHOSPHATE, Sodium phosphate, dibasic, SODIUM PHOSPHATE, DIBASIC ANHYDROUS, Caswell No. 778, Disodium hydrogen phosphate, anhydrous (+15 more)
CAS 7558-79-4
Dibasic sodium phosphate (CAS 7558-79-4) is a chemical substance. Key regulatory status: REACH registered, 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
26
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Dibasic sodium phosphate
CAS Number
7558-79-4
DTXSID
DTXSID1026039
Molecular Formula
2Na.H3O4P
InChI Key
BNIILDVGGAEEIG-UHFFFAOYSA-L
Monoisotopic Mass
143.956434
Synonyms
DISODIUM HYDROGEN PHOSPHATESodium phosphate, dibasicSODIUM PHOSPHATE, DIBASIC ANHYDROUSCaswell No. 778Disodium hydrogen phosphate, anhydrousDisodium phosphate, anhydrousDisodium phosphoric acidEINECS 231-448-7EPA Pesticide Chemical Code 076403FEMA No. 2398FEMA Number 2398Phosphate of soda
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes mild skin irritation Causes eye irritation |
| Short-term Effects | The substance is mildly irritating to the eyes, skin and respiratory tract. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DeodorizerpH regulating agentCorrosion inhibitorFragranceThickening agentAnti-scaling agentChelating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.07 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =15.47 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 22ADO53M6F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 22ADO53M6F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 22ADO53M6F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 22ADO53M6F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4345 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4590 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 10000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =49 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium hydrogenorthophosphate | 231-448-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
buffering agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS
ChEMBL Phase
4
Adverse Events
61
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E339 — ADI: 70 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dibasic sodium phosphate?
Dibasic sodium phosphate appears on 12 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 9 more. Source: EPA CPDat.
Is Dibasic sodium phosphate used in cosmetics?
Yes, Dibasic sodium phosphate is also indexed as a cosmetic ingredient under the name Disodium Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibasic sodium phosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dibasic sodium phosphate used outside industrial chemicals?
Dibasic sodium phosphate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.