Is Dioxolane (1,3-Dioxolane) safe in cosmetics?
Dioxolane (1,3-Dioxolane) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dioxolane (1,3-Dioxolane)
Also known as: EINECS 211-463-5, Glycol formal, UNII-Y57RBG19JL
Dioxolane (1,3-Dioxolane) (CAS 646-06-0) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 75 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 646-06-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dioxolane (1,3-Dioxolane) is classified GHS Danger (H225, H319, H360, H303, H316, H341, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3-dioxolane
InChIKey
WNXJIVFYUVYPPR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dioxolane (1,3-Dioxolane).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dioxolane (1,3-Dioxolane) across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Dioxolane (1,3-Dioxolane).
Known Synonyms
EINECS 211-463-5
Glycol formal
UNII-Y57RBG19JL
Chemical Function
Solvent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187281
Frequently Asked Questions
Is Dioxolane (1,3-Dioxolane) allowed in the EU?
Dioxolane (1,3-Dioxolane) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dioxolane (1,3-Dioxolane) do in cosmetics?
Dioxolane (1,3-Dioxolane) functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 646-06-0.
Is Dioxolane (1,3-Dioxolane) used outside cosmetics?
Dioxolane (1,3-Dioxolane) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dioxolane (1,3-Dioxolane) have different safety status in cosmetics vs industrial chemicals?
Dioxolane (1,3-Dioxolane) is classified GHS Danger (H225, H319, H360, H303, H316, H341, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dioxolane (1,3-Dioxolane) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
C10-13 Isoparaffin
Excellent
Same category
Solvent
C9-14 Isoparaffin
Excellent
Same category
Solvent
PPG-10 Butanediol
Excellent
Same category
Solvent
Phosphate Buffered Saline
Excellent
Same category
Solvent, buffering agent
Water
Excellent
Same category
Solvent, vehicle/carrier
1,10-Decanediol
Good
Same category
Solvent
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
DIOXOLANE
Good
Chemical family
Solvent
Isobutyl Stearate
Excellent
Chemical family
Emollient / skin conditioning agent
DIOSCOREA JAPONICA FRUIT/CALCIUM HYDROXIDE/MAGNESIUM HYDROXIDE/POTASSIUM OXIDE/SILICA/SODIUM HYDROXIDE/SUCROSE FERMENT FILTRATE
Good
Browse nearby
Skin Conditioning, Skin Protecting
Is Dioxolane (1,3-Dioxolane) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dioxolane (1,3-Dioxolane) in your formulation.