What is the GHS hazard classification for 1,3-Dioxolane?
1,3-Dioxolane (CAS 646-06-0) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).
Danger
GHS02
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Dioxolane
Also known as: EINECS 211-463-5, Glycol formal, UNII-Y57RBG19JL
CAS 646-06-0
1,3-Dioxolane (CAS 646-06-0) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, OSHA.
View cosmetic safety profile for Dioxolane (1,3-Dioxolane) →
Cross-Vertical Regulatory Divergence
1,3-Dioxolane is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
9 fields
Name
1,3-Dioxolane
CAS Number
646-06-0
DTXSID
DTXSID4027284
Molecular Formula
C3H6O2
InChI Key
WNXJIVFYUVYPPR-UHFFFAOYSA-N
Monoisotopic Mass
74.036779
Synonyms
EINECS 211-463-5Glycol formalUNII-Y57RBG19JL
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2 | H225 | GHS02 | Danger |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
1 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 20 ppm [1997] | 20 | - | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.306 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =18.15 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Y57RBG19JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y57RBG19JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y57RBG19JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Y57RBG19JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20.65 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =200 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =250 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| >378.729 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =500 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =7026.18 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =9119.79 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =60 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =75 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =902.89 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =1563.39 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
| =3029.83 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_HPVIS |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,3-dioxolane | 211-463-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3187281
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for 1,3-Dioxolane?
1,3-Dioxolane has 25 NOAEL studies in the database. The lowest reported value is 3.306 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include 1,3-Dioxolane?
1,3-Dioxolane appears on 1 regulatory/inventory list including drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.
What are the occupational exposure limits for 1,3-Dioxolane?
Occupational exposure limits for 1,3-Dioxolane are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 1,3-Dioxolane used in cosmetics?
Yes, 1,3-Dioxolane is also indexed as a cosmetic ingredient under the name Dioxolane (1,3-Dioxolane). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Dioxolane come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,3-Dioxolane have different safety status in cosmetics vs industrial chemicals?
1,3-Dioxolane is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
Is 1,3-Dioxolane used outside industrial chemicals?
1,3-Dioxolane also appears in cosmetics, pharmaceutical, cannabis databases.