Is DIOXOLANE safe in cosmetics?
DIOXOLANE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
DIOXOLANE
Also known as: EINECS 211-463-5, Glycol formal, UNII-Y57RBG19JL
DIOXOLANE (CAS 646-06-0) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 75 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 646-06-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DIOXOLANE is classified GHS Danger (H225, H319, H360, H303, H316, H341, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Chemistry & Identifiers
IUPAC Name
1,3-dioxolane
InChIKey
WNXJIVFYUVYPPR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for DIOXOLANE across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for DIOXOLANE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
EINECS 211-463-5
Glycol formal
UNII-Y57RBG19JL
Chemical Function
Solvent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Frequently Asked Questions
Is DIOXOLANE allowed in the EU?
DIOXOLANE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DIOXOLANE do in cosmetics?
DIOXOLANE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 646-06-0.
Is DIOXOLANE used outside cosmetics?
DIOXOLANE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DIOXOLANE have different safety status in cosmetics vs industrial chemicals?
DIOXOLANE is classified GHS Danger (H225, H319, H360, H303, H316, H341, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check DIOXOLANE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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