Is Dimethyltolylamine safe in cosmetics?
Dimethyltolylamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Dimethyltolylamine
Also known as: N,N-Dimethyl-p-toluidine, EINECS 202-805-4, Dimetil-p-toluidina, UNII-S8XC5939VU
INCI: DIMETHYLTOLYLAMINE
Dimethyltolylamine (CAS 99-97-8) is a cosmetic cosmetic ingredient functioning as Nail product catalyst / accelerator. NOAEL 2 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 99-97-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyltolylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H331, H373, H410, H412, H317, H351).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Nail product catalyst / accelerator
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
N,N,4-trimethylaniline
InChIKey
GYVGXEWAOAAJEU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not specifically prohibited under 21 CFR; however, CMR classification may trigger MoCRA review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyltolylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCancerHealth haz
Hazard Statements
Fatal if inhaled Harmful if swallowed or in contact with skin May cause damage to kidneys and liver through prolonged or repeated exposure Suspected of causing cancer Harmful to aquatic life with long lasting effects
Short-term Exposure Effects
The substance may cause effects on the red blood cells. This may result in the formation of methaemoglobin. The effects may be delayed.
Long-term Exposure Effects
The substance may have effects on the kidneys and liver. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dimethyltolylamine across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
115
Evaluation Year
2016
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardAcute Toxicity
Hazard Class and Category
Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT RE 2; Aquatic Chronic 3
Hazard Statements
- H350 May cause cancer
- H332 Harmful if inhaled
- H301 Toxic if swallowed
- H373 (blood system
- respiratory tract)
- H412 Harmful to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 1.4 mg/L dusts or mists; oral: ATE = 140.0 mg/kg bw
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1745
(EU) 2025/877
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited (Sep 2025))
CMR substance (category 1B)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| SA | banned | - | All cosmetics |
| BR | banned | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
N,N-Dimethyl-p-toluidine | Group 2B: Possibly carcinogenic to humans | Volume 115: (2018) Some Industrial Chemicals
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
N,N-Dimethyl-p-Toluidine | TR-579: Toxicology and Carcinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) (2012 ) | 02/08/12 | Clear Evidence | Clear Evidence | Clear Evidence | Clear Evidence | Under the conditions of these 2-year oral gavage studies, there was clear evidence of carcinogenic activity of N,N-dimethyl-p-toluidine
Source: NTP Technical Reports
ICSC Safety Card
0456
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Hardener
Softener and conditioner
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyltolylamine.
Regulatory Flags
prop65
Known Synonyms
N,N-Dimethyl-p-toluidine
EINECS 202-805-4
Dimetil-p-toluidina
UNII-S8XC5939VU
Chemical Function
Softener and conditioner
Catalyst
Hardener
Regulatory Lists
detected; Europe; Personal care - nails - nail polish
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1462714
Frequently Asked Questions
Is Dimethyltolylamine allowed in the EU?
Dimethyltolylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyltolylamine do in cosmetics?
Dimethyltolylamine functions as: Nail product catalyst / accelerator. It is classified as a cosmetic ingredient in our database. CAS number: 99-97-8.
Is Dimethyltolylamine classified as hazardous under GHS?
Dimethyltolylamine carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful if swallowed or in contact with skin May cause damage to kidneys and liver through prolonged or repeated exposure Suspected of causing cancer Harmful to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Dimethyltolylamine used outside cosmetics?
Dimethyltolylamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyltolylamine have different safety status in cosmetics vs industrial chemicals?
Dimethyltolylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H331, H373, H410, H412, H317, H351).
Compliance Tools
Check Dimethyltolylamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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