Also known as: N,N-Dimethyl-p-toluidine, EINECS 202-805-4, Dimetil-p-toluidina, UNII-S8XC5939VU
CAS 99-97-8
N,N,4-Trimethylaniline (CAS 99-97-8) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H332; H301; H373 (blood system, respiratory tract); H412. Key regulatory status: California Proposition 65, REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC.
N,N,4-Trimethylaniline is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H332, H301, H373, H412).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2016 | 115 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT RE 2; Aquatic Chronic 3 | H350; H332; H301; H373 (blood system, respiratory tract); H412 | GHS08; GHS06 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Fatal if inhaled Harmful if swallowed or in contact with skin May cause damage to kidneys and liver through prolonged or repeated exposure Suspected of causing cancer Harmful to aquatic life with long lasting effects |
| Short-term Effects | The substance may cause effects on the red blood cells. This may result in the formation of methaemoglobin. The effects may be delayed. |
| Long-term Effects | The substance may have effects on the kidneys and liver. This substance is possibly carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 56.4224874697343 | uM | AC50 | - | - | NTP ICE endocrine |
| 214.513179777622 | uM | ACC | - | - | NTP ICE endocrine |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 20.38 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =0.128 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =1.352 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| S8XC5939VU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S8XC5939VU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S8XC5939VU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S8XC5939VU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.05498 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP ICE cancer |
| 1.4 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =1650 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =6 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | LEL | oral | Mouse | ECHA |
| =800 | mg/m3 | LEL | inhalation | Mouse | ECHA |
| =3192 | mg/m3 | LEL | inhalation | Mouse | ECHA |
| =6 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =20 | mg/kg bw/day | LOAEL | oral | Mouse | ECHA |
| =30 | mg/kg bw/day | LOAEL | oral | Mouse | ECHA |
| =62.5 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00737 | unitless | Model Score | - | - | NTP ICE endocrine |
| >- | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =19.1 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| 20 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP ICE cancer |
| 60 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Rat | NTP ICE cancer |
| 60 | mg/kg | Top dose | Gavage | Mouse | NTP ICE cancer |
Showing 35 of 35 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N,N-dimethyl-p-toluidine | 202-805-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
N,N,4-Trimethylaniline (CAS 99-97-8) is classified under EU CLP Annex VI as Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT RE 2; Aquatic Chronic 3 with signal word Danger. Hazard statements: H350; H332; H301; H373 (blood system, respiratory tract); H412. Source: EU CLP Annex VI (ECHA).
N,N,4-Trimethylaniline has 35 NOAEL studies in the database. The lowest reported value is 56.4224874697343 uM. Source: NTP ICE endocrine.
N,N,4-Trimethylaniline appears on 4 regulatory/inventory lists including detected; Europe; Personal care - nails - nail polish, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), and 1 more. Source: EPA CPDat.
N,N,4-Trimethylaniline is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2016). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, N,N,4-Trimethylaniline is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, N,N,4-Trimethylaniline is also indexed as a cosmetic ingredient under the name Dimethyltolylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
N,N,4-Trimethylaniline is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H332, H301, H373, H412).
N,N,4-Trimethylaniline also appears in cosmetics, pharmaceutical databases.