Is Dimethylolcyclohexane safe in cosmetics?
Dimethylolcyclohexane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Dimethylolcyclohexane
Also known as: BRN 1902271, Cyclohexane-1,4-dimethanol, EINECS 203-268-9, UNII-8C3FKR6R1B
INCI: DIMETHYLOLCYCLOHEXANE
Dimethylolcyclohexane (CAS 105-08-8) is a cosmetic cosmetic ingredient functioning as Solvent, emollient, polymer precursor. Reported NOAEL =5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 105-08-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethylolcyclohexane is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, emollient, polymer precursor
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[4-(hydroxymethyl)cyclohexyl]methanol
InChIKey
YIMQCDZDWXUDCA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylolcyclohexane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Dimethylolcyclohexane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =200 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =400 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =700 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dimethylolcyclohexane.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethylolcyclohexane by CAS number or substance name.
Studies
5
Lowest NOAEL
5 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
BRN 1902271
Cyclohexane-1,4-dimethanol
EINECS 203-268-9
UNII-8C3FKR6R1B
Chemical Function
Solvent
No specific technical function
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dimethylolcyclohexane allowed in the EU?
Dimethylolcyclohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylolcyclohexane do in cosmetics?
Dimethylolcyclohexane functions as: Solvent, emollient, polymer precursor. It is classified as a cosmetic ingredient in our database. CAS number: 105-08-8.
What is the NOAEL for Dimethylolcyclohexane?
The NOAEL (No Observed Adverse Effect Level) for Dimethylolcyclohexane is =5 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Dimethylolcyclohexane used outside cosmetics?
Dimethylolcyclohexane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethylolcyclohexane have different safety status in cosmetics vs industrial chemicals?
Dimethylolcyclohexane is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dimethylolcyclohexane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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