What is the NOAEL for 1,4-Cyclohexanedimethanol?
1,4-Cyclohexanedimethanol has 12 NOAEL studies in the database. The lowest reported value is 30.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,4-Cyclohexanedimethanol
Also known as: BRN 1902271, Cyclohexane-1,4-dimethanol, EINECS 203-268-9, UNII-8C3FKR6R1B
CAS 105-08-8
1,4-Cyclohexanedimethanol (CAS 105-08-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
1,4-Cyclohexanedimethanol is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
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chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
10 fields
Name
1,4-Cyclohexanedimethanol
CAS Number
105-08-8
DTXSID
DTXSID9026712
Molecular Formula
C8H16O2
InChI Key
YIMQCDZDWXUDCA-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
BRN 1902271Cyclohexane-1,4-dimethanolEINECS 203-268-9UNII-8C3FKR6R1B
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
SolventNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =30.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8C3FKR6R1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8C3FKR6R1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8C3FKR6R1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =400 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =800 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =400 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =700 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =854 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cyclohex-1,4-ylenedimethanol | 203-268-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,4-Cyclohexanedimethanol?
1,4-Cyclohexanedimethanol appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 1,4-Cyclohexanedimethanol used in cosmetics?
Yes, 1,4-Cyclohexanedimethanol is also indexed as a cosmetic ingredient under the name Dimethylolcyclohexane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Cyclohexanedimethanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,4-Cyclohexanedimethanol have different safety status in cosmetics vs industrial chemicals?
1,4-Cyclohexanedimethanol is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is 1,4-Cyclohexanedimethanol used outside industrial chemicals?
1,4-Cyclohexanedimethanol also appears in cosmetics, cannabis databases.