Is Dimethylaminoethyl Methacrylate (DMAEMA) safe in cosmetics?
Dimethylaminoethyl Methacrylate (DMAEMA) has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Dimethylaminoethyl Methacrylate (DMAEMA)
Also known as: 2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, Methacrylic acid, 2-(dimethylamino)ethyl ester, Acryester DM, NSC 20959, 4-04-00-01432 (+7 more)
INCI: DIMETHYLAMINOETHYL METHACRYLATE
Dimethylaminoethyl Methacrylate (DMAEMA) (CAS 2867-47-2) is a cosmetic cosmetic ingredient functioning as Monomer for synthesis of hair-fixing and film-forming polymers. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2867-47-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethylaminoethyl Methacrylate (DMAEMA) is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H303) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Monomer for synthesis of hair-fixing and film-forming polymers
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-(dimethylamino)ethyl 2-methylprop-2-enoate
InChIKey
JKNCOURZONDCGV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as polymerisation feedstock; no specific CFR prohibition for cosmetic use; classified Acute Tox. 4 (oral + dermal)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylaminoethyl Methacrylate (DMAEMA).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
Corr
Hazard Statements
Combustible liquid Causes severe skin burns and eye damage Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes and skin. The substance is irritating to the respiratory tract. Corrosive on ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dimethylaminoethyl Methacrylate (DMAEMA) across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0450
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to skin, eyes, and mucous membranes.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Viscosity modifier
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dimethylaminoethyl Methacrylate (DMAEMA).
Regulatory Flags
potential-allergen
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester
Methacrylic acid, 2-(dimethylamino)ethyl ester
Acryester DM
NSC 20959
4-04-00-01432
Ageflex FM-1
BRN 1757048
beta-Dimethylaminoethyl methacrylate
EINECS 220-688-8
Ethanol, 2-(dimethylamino)-, methacrylate
2-Dimethylaminoethylester kyseliny methakrylove
UNII-O0V97PV2G1
Chemical Function
Film former
Viscosity modifier
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1883484
Frequently Asked Questions
Is Dimethylaminoethyl Methacrylate (DMAEMA) allowed in the EU?
Dimethylaminoethyl Methacrylate (DMAEMA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylaminoethyl Methacrylate (DMAEMA) do in cosmetics?
Dimethylaminoethyl Methacrylate (DMAEMA) functions as: Monomer for synthesis of hair-fixing and film-forming polymers. It is classified as a cosmetic ingredient in our database. CAS number: 2867-47-2.
Is Dimethylaminoethyl Methacrylate (DMAEMA) classified as hazardous under GHS?
Dimethylaminoethyl Methacrylate (DMAEMA) carries a GHS signal word of "DANGER". Hazard statements: Combustible liquid Causes severe skin burns and eye damage Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Dimethylaminoethyl Methacrylate (DMAEMA) used outside cosmetics?
Dimethylaminoethyl Methacrylate (DMAEMA) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethylaminoethyl Methacrylate (DMAEMA) have different safety status in cosmetics vs industrial chemicals?
Dimethylaminoethyl Methacrylate (DMAEMA) is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H303) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dimethylaminoethyl Methacrylate (DMAEMA) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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