Is Dimethyl Oxazolidine safe in cosmetics?
Dimethyl Oxazolidine has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Dimethyl Oxazolidine
Also known as: 4,4-Dimethyloxazolidine, Oxazolidine, 4,4-dimethyl-, BRN 0969276, Caswell No. 374AB, EINECS 257-048-2 (+3 more)
INCI: DIMETHYL OXAZOLIDINE
Dimethyl Oxazolidine (CAS 51200-87-4) is a cosmetic cosmetic ingredient functioning as Preservative / antimicrobial (formaldehyde-releasing biocide). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 51200-87-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyl Oxazolidine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H312, H315, H318, H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative / antimicrobial (formaldehyde-releasing biocide)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4,4-dimethyl-1,3-oxazolidine
InChIKey
GUQMDNQYMMRJPY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR ban; however, formaldehyde donors are under increasing scrutiny
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Oxazolidine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Max: 0.1%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Preservative. Max: 0.05%. pH must exceed 6
SA Saudi SFDA (V - Preservatives)
Max: 0.001.
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max 0,1%
India: Permitted Preservative · max 0.001
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.1 | all cosmetics |
| IN | permitted_preservative | 0.2 | all cosmetics |
| BR | permitted_preservative | 0.1 | Prohibited in products with pH ≤6 |
| ASEAN | permitted_preservative | 0.1% | All products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Dimethyloxazolidine has been placed in Toxicity Category I (the highest of four categories) for its effects as a severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Oxazolidine.
Regulatory Flags
potential-allergen
preservative
eu_cosing_listed
Known Synonyms
4,4-Dimethyloxazolidine
Oxazolidine, 4,4-dimethyl-
BRN 0969276
Caswell No. 374AB
EINECS 257-048-2
EPA Pesticide Chemical Code 114801
Oxazolidine A
UNII-96J42P99ZA
Chemical Function
Preservative
Biocide
Regulatory Lists
Europe; Personal care
Arts and crafts/Office supplies - fabric treatment and dye; detected
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3560963
Frequently Asked Questions
Is Dimethyl Oxazolidine allowed in the EU?
Dimethyl Oxazolidine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Oxazolidine do in cosmetics?
Dimethyl Oxazolidine functions as: Preservative / antimicrobial (formaldehyde-releasing biocide). It is classified as a cosmetic ingredient in our database. CAS number: 51200-87-4.
Is Dimethyl Oxazolidine used outside cosmetics?
Dimethyl Oxazolidine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Oxazolidine have different safety status in cosmetics vs industrial chemicals?
Dimethyl Oxazolidine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H312, H315, H318, H317, H319).
Compliance Tools
Check Dimethyl Oxazolidine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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