What is the NOAEL for 4,4-Dimethyl oxazolidine?
4,4-Dimethyl oxazolidine has 21 NOAEL studies in the database. The lowest reported value is 96J42P99ZA UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4,4-Dimethyl oxazolidine
Also known as: 4,4-Dimethyloxazolidine, Oxazolidine, 4,4-dimethyl-, BRN 0969276, Caswell No. 374AB, EINECS 257-048-2 (+3 more)
CAS 51200-87-4
4,4-Dimethyl oxazolidine (CAS 51200-87-4) is a chemical substance. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4,4-Dimethyl oxazolidine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H312, H315, H318, H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
29
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
4,4-Dimethyl oxazolidine
CAS Number
51200-87-4
DTXSID
DTXSID0032314
Molecular Formula
C5H11NO
InChI Key
GUQMDNQYMMRJPY-UHFFFAOYSA-N
Monoisotopic Mass
101.084064
Synonyms
4,4-DimethyloxazolidineOxazolidine, 4,4-dimethyl-BRN 0969276Caswell No. 374ABEINECS 257-048-2EPA Pesticide Chemical Code 114801Oxazolidine AUNII-96J42P99ZA
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
PreservativeBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
29 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 96J42P99ZA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96J42P99ZA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96J42P99ZA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96J42P99ZA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =950 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1037 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| =1038 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| =19.5 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ToxRefDB |
| =19.5 | mg/kg bw/day | LEL | dermal | rat ([Not Reported]) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =30 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ToxRefDB |
| =30 | mg/kg bw/day | LEL | dermal | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >300 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ToxRefDB |
| >300 | mg/kg bw/day | LEL | dermal | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =195 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ToxRefDB |
| =195 | mg/kg bw/day | LOAEL | dermal | rat ([Not Reported]) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >- | mg/kg bw/day | NEL | dermal | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1 | mg/kg bw/day | NEL | dermal | Rat | ToxValDB_ToxRefDB |
| =1 | mg/kg bw/day | NEL | dermal | rat (sprague dawley; Sprague Dawley (CD)) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1.95 | mg/kg bw/day | NEL | dermal | Rat | ToxValDB_ToxRefDB |
| =1.95 | mg/kg bw/day | NEL | dermal | rat ([Not Reported]) | ToxRefDB_ToxRefDB_v3_pod.csv |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4,4-dimethyloxazolidine | 257-048-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3560963
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 4,4-Dimethyl oxazolidine?
4,4-Dimethyl oxazolidine appears on 7 regulatory/inventory lists including Europe; Personal care, Arts and crafts/Office supplies - fabric treatment and dye; detected, Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe, and 4 more. Source: EPA CPDat.
Is 4,4-Dimethyl oxazolidine used in cosmetics?
Yes, 4,4-Dimethyl oxazolidine is also indexed as a cosmetic ingredient under the name Dimethyl Oxazolidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4-Dimethyl oxazolidine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4,4-Dimethyl oxazolidine have different safety status in cosmetics vs industrial chemicals?
4,4-Dimethyl oxazolidine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H332, H312, H315, H318, H317, H319).
Is 4,4-Dimethyl oxazolidine used outside industrial chemicals?
4,4-Dimethyl oxazolidine also appears in cosmetics, pharmaceutical databases.