Is Dimethyl Carbonate safe in cosmetics?
Dimethyl Carbonate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dimethyl Carbonate
Also known as: EINECS 210-478-4, UNII-KE9J097SPN, DMC
INCI: DIMETHYL CARBONATE
Dimethyl Carbonate (CAS 616-38-6) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =1000 mg/kg bw/day in Rabbit (ECHA); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 616-38-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyl Carbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H361, H336).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dimethyl carbonate
InChIKey
IEJIGPNLZYLLBP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under 21 CFR 700, not prohibited
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Carbonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rabbit | reproduction developmental | ECHA |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is mildly irritating to the eyes.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1080
Source: WHO/JECFA
Skin Eye Respiratory Irritation
Irritating to skin, eye, and respiratory system.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Propellants
non-motive (blowing agents)
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Carbonate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethyl Carbonate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
EINECS 210-478-4
UNII-KE9J097SPN
DMC
Chemical Function
Solvent
Propellants
non-motive (blowing agents)
Deodorizer
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185216
Frequently Asked Questions
Is Dimethyl Carbonate allowed in the EU?
Dimethyl Carbonate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Carbonate do in cosmetics?
Dimethyl Carbonate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 616-38-6.
What is the NOAEL for Dimethyl Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Carbonate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rabbit. Source: ECHA.
Is Dimethyl Carbonate used outside cosmetics?
Dimethyl Carbonate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Carbonate have different safety status in cosmetics vs industrial chemicals?
Dimethyl Carbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H361, H336).
Compliance Tools
Check Dimethyl Carbonate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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