NOAEL Studies Cosmetic Ingredient

Dimethyl Carbonate NOAEL Studies

INCI: DIMETHYL CARBONATE

CAS: 616-38-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >5.36 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5153; Record_ID=acute_inhalation_988; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9029192; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.36; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14944/7/3/3/?documentUUID=835ac5d1-6566-482b-b12b-24e6286830ee; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192
NTP ICE acute inhalation LC50 >18.4094 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5152; Record_ID=acute_inhalation_1026; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9029192; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=18.4094; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14944/7/3/3/?documentUUID=f33b57c2-d4af-495c-8c9c-acb7a6f727c9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8418; row=15756; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl carbonate; preferred_name=Dimethyl carbonate; dtxsid=DTXSID9029192; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =13000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8420; row=15755; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl carbonate; preferred_name=Dimethyl carbonate; dtxsid=DTXSID9029192; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192; source_file=acute_oral.xlsx
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8996; Record_ID=skin_sensitization_invivo_1996; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9029192; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192
NTP ICE skin sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8994; Record_ID=skin_sensitization_invivo_1996; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9029192; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9000; Record_ID=skin_sensitization_invivo_1996; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9029192; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029192
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =1000 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be4d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17182/7/9/3?documentUUID=4eec6be8-9cce-4d0c-a335-993bfea472da; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823436_15823561:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a50e1fda356571c1fe82cf14dfbd7a21
ECHA NOEL >500 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7fe4b0a7c65d1c9963; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17182/7/6/2?documentUUID=4eec6be8-9cce-4d0c-a335-993bfea472da; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15849627:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bb709c4741e0d48cb705eaa75baba86f
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =34.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631372:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42ab17eae00f1a95377a54b80c4cb0bd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KE9J097SPN UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KE9J097SPN"}
openFDA substances FDA UNII substance identifier KE9J097SPN UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KE9J097SPN"}
openFDA substances FDA UNII substance identifier KE9J097SPN UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KE9J097SPN"}
openFDA substances FDA UNII substance identifier KE9J097SPN UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KE9J097SPN"}