What is the GHS hazard classification for Dimethyl carbonate?
Dimethyl carbonate (CAS 616-38-6) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).
Danger
GHS02
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl carbonate
Also known as: EINECS 210-478-4, UNII-KE9J097SPN, DMC
CAS 616-38-6
Dimethyl carbonate (CAS 616-38-6) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Dimethyl carbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Dimethyl carbonate
CAS Number
616-38-6
DTXSID
DTXSID9029192
Molecular Formula
C3H6O3
InChI Key
IEJIGPNLZYLLBP-UHFFFAOYSA-N
Monoisotopic Mass
90.031694
Synonyms
EINECS 210-478-4UNII-KE9J097SPNDMC
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2 | H225 | GHS02 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The vapour is mildly irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
SolventPropellants, non-motive (blowing agents)Deodorizer
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =34.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| KE9J097SPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE9J097SPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE9J097SPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE9J097SPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5.36 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >18.4094 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =13000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >500 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl carbonate | 210-478-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3185216
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Dimethyl carbonate?
Dimethyl carbonate has 14 NOAEL studies in the database. The lowest reported value is 34.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Is Dimethyl carbonate used in cosmetics?
Yes, Dimethyl carbonate is also indexed as a cosmetic ingredient under the name Dimethyl Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl carbonate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dimethyl carbonate have different safety status in cosmetics vs industrial chemicals?
Dimethyl carbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
Is Dimethyl carbonate used outside industrial chemicals?
Dimethyl carbonate also appears in cosmetics, pharmaceutical, cannabis databases.