Is Diisononyl Adipate safe in cosmetics?
Diisononyl Adipate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Diisononyl Adipate
Also known as: Adipic acid, diisononyl ester, Isononyl alcohol, adipate (2:1), Hexanedioic acid, 1,6-diisononyl ester, Hexanedioic acid, diisononyl ester, EINECS 251-646-7 (+13 more)
Diisononyl Adipate (CAS 33703-08-1) is a cosmetic cosmetic ingredient functioning as Plasticizer; Softener and conditioner; Solvent. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 33703-08-1 →
Auto-generated CPSR Part A draft with source citations
Function
Plasticizer; Softener and conditioner; Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
bis(7-methyloctyl) hexanedioate
InChIKey
AYWLCKHHUFBVGJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 31(Suppl 1):5-76, 2012
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisononyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diisononyl Adipate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diisononyl Adipate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diisononyl Adipate by CAS number or substance name.
Studies
9
Lowest NOAEL
145 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Adipic acid, diisononyl ester
Isononyl alcohol, adipate (2:1)
Hexanedioic acid, 1,6-diisononyl ester
Hexanedioic acid, diisononyl ester
EINECS 251-646-7
UNII-BMQ5JF4857
DINA
Glissofluid A 13
Jayflex DINA
Jayflex DINA 2
Monocizer W 242
Plastomoll DNA
Polycizer W 242
Sansocizer DINA
W 242
Plasomoll DNA
EC No.: 251-646-7
251-646-7
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Regulatory Lists
Indirect additives food contact (10/2018)
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188864
Frequently Asked Questions
Is Diisononyl Adipate allowed in the EU?
Diisononyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisononyl Adipate do in cosmetics?
Diisononyl Adipate functions as: Plasticizer; Softener and conditioner; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 33703-08-1.
Is Diisononyl Adipate used outside cosmetics?
Diisononyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diisononyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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