What is the NOAEL for Diisononyl adipate?
Diisononyl adipate has 8 NOAEL studies in the database. The lowest reported value is 8.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diisononyl adipate
Also known as: Adipic acid, diisononyl ester, Isononyl alcohol, adipate (2:1), Hexanedioic acid, 1,6-diisononyl ester, Hexanedioic acid, diisononyl ester, EINECS 251-646-7 (+13 more)
CAS 33703-08-1
Diisononyl adipate (CAS 33703-08-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Diisononyl adipate
CAS Number
33703-08-1
DTXSID
DTXSID5027982
Synonyms
Adipic acid, diisononyl esterIsononyl alcohol, adipate (2:1)Hexanedioic acid, 1,6-diisononyl esterHexanedioic acid, diisononyl esterEINECS 251-646-7UNII-BMQ5JF4857DINAGlissofluid A 13Jayflex DINAJayflex DINA 2Monocizer W 242Plastomoll DNA
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
SolventSoftener and conditionerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| BMQ5JF4857 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BMQ5JF4857 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BMQ5JF4857 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BMQ5JF4857 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| ~274 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_HPVIS |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diisononyl adipate | 251-646-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188864
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diisononyl adipate?
Diisononyl adipate appears on 2 regulatory/inventory lists including Indirect additives food contact (10/2018), Europe; plastic_additive. Source: EPA CPDat.
Is Diisononyl adipate used in cosmetics?
Yes, Diisononyl adipate is also indexed as a cosmetic ingredient under the name Diisononyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diisononyl adipate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diisononyl adipate used outside industrial chemicals?
Diisononyl adipate also appears in cosmetics, pharmaceutical databases.