Is Diisodecyl Adipate safe in cosmetics?
Diisodecyl Adipate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Diisodecyl Adipate
Also known as: Diisodecyl adipate (Hexanedioic acid, diisodecyl ester), Hexanedioic acid, diisodecyl ester, EINECS 248-299-9, UNII-3V0Q382O0P, C9(C)O(=O)CCCC(=O)O(C)C9
INCI: DIISODECYL ADIPATE
Diisodecyl Adipate (CAS 27178-16-1) is a cosmetic cosmetic ingredient functioning as Emollient, moisturizing, skin conditioning, smoothing, solvent. Reported NOAEL =178 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 27178-16-1 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, moisturizing, skin conditioning, smoothing, solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
bis(8-methylnonyl) hexanedioate
InChIKey
YKGYQYOQRGPFTO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — also FDA food-contact approved under 21 CFR 175.105 and 177.2600
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisodecyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diisodecyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =178 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =203 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Lubricating agent
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diisodecyl Adipate.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diisodecyl Adipate by CAS number or substance name.
Studies
2
Lowest NOAEL
178 mg/kg bw/day
Highest NOAEL
203 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Diisodecyl adipate (Hexanedioic acid, diisodecyl ester)
Hexanedioic acid, diisodecyl ester
EINECS 248-299-9
UNII-3V0Q382O0P
C9(C)O(=O)CCCC(=O)O(C)C9
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Fragrance
Regulatory Lists
IFRA Transparency
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182959
Frequently Asked Questions
Is Diisodecyl Adipate allowed in the EU?
Diisodecyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisodecyl Adipate do in cosmetics?
Diisodecyl Adipate functions as: Emollient, moisturizing, skin conditioning, smoothing, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 27178-16-1.
What is the NOAEL for Diisodecyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Diisodecyl Adipate is =178 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Diisodecyl Adipate used outside cosmetics?
Diisodecyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diisodecyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acacia Decurrens/Jojoba/Sunflower Seed Wax Polyglyceryl-3 Esters
Excellent
Same category
Skin conditioning emollient, texturizer
Acetic/Linoleic/Palmitic Triglyceride
Excellent
Same category
Skin conditioning (emollient)
Acetyl Ornithine
Excellent
Same category
Emollient
Acetyl Proline
Excellent
Same category
Emollient
Acetyl Triethylhexyl Citrate
Excellent
Same category
Emollient, Film Forming, Plasticiser
Acetyl Trihexyl Citrate
Excellent
Same category
Plasticiser, Skin Conditioning (Emoll...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
Good
Similar safety
Humectant, Skin Conditioning - Humect...
DIISONONYL PHTHALATE
Good
Browse nearby
Anticaking
DIMER AMIDE
Good
Browse nearby
Antimicrobial
DIMETHICONE/METHICONE COPOLYMER
Good
Browse nearby
Anticaking
Is Diisodecyl Adipate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diisodecyl Adipate in your formulation.