What is the NOAEL for Diisodecyl hexanedioate?
Diisodecyl hexanedioate has 10 NOAEL studies in the database. The lowest reported value is 2.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diisodecyl hexanedioate
Also known as: Diisodecyl adipate (Hexanedioic acid, diisodecyl ester), Hexanedioic acid, diisodecyl ester, EINECS 248-299-9, UNII-3V0Q382O0P, C9(C)O(=O)CCCC(=O)O(C)C9
CAS 27178-16-1
Diisodecyl hexanedioate (CAS 27178-16-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Diisodecyl hexanedioate
CAS Number
27178-16-1
DTXSID
DTXSID1027924
Synonyms
Diisodecyl adipate (Hexanedioic acid, diisodecyl ester)Hexanedioic acid, diisodecyl esterEINECS 248-299-9UNII-3V0Q382O0PC9(C)O(=O)CCCC(=O)O(C)C9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
SolventSoftener and conditionerPlasticizerFragranceLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3V0Q382O0P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3V0Q382O0P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3V0Q382O0P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3V0Q382O0P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =178 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =203 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=2102 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=2399 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diisodecyl adipate | 248-299-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182959
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diisodecyl hexanedioate?
Diisodecyl hexanedioate appears on 2 regulatory/inventory lists including IFRA Transparency, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Diisodecyl hexanedioate used in cosmetics?
Yes, Diisodecyl hexanedioate is also indexed as a cosmetic ingredient under the name Diisodecyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diisodecyl hexanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diisodecyl hexanedioate used outside industrial chemicals?
Diisodecyl hexanedioate also appears in cosmetics, pharmaceutical databases.