Is Diisobutyl Sodium Sulfosuccinate safe in cosmetics?
Diisobutyl Sodium Sulfosuccinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Diisobutyl Sodium Sulfosuccinate
Also known as: Butanedioic acid, sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt, 1,4-Bis(2-methylpropyl)sulfobutanyedioate, sodium salt, Butanedioic acid, 2-sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt (1:1), Succinic acid, sulfo-, 1,4-diisobutyl ester, sodium salt, EINECS 204-839-5 (+1 more)
INCI: DIISOBUTYL SODIUM SULFOSUCCINATE
Diisobutyl Sodium Sulfosuccinate (CAS 127-39-9) is a cosmetic cosmetic ingredient functioning as Surfactant, wetting agent, foam booster, skin conditioning. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 127-39-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diisobutyl Sodium Sulfosuccinate is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Surfactant, wetting agent, foam booster, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium 1,4-bis(2-methylpropoxy)-1,4-dioxobutane-2-sulfonate
InChIKey
NTWXWSVUSTYPJH-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR reviewed; FDA VCRP listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisobutyl Sodium Sulfosuccinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diisobutyl Sodium Sulfosuccinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =750 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diisobutyl Sodium Sulfosuccinate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Foamant
Softener and conditioner
Solubility enhancer
Surfactant (surface active agent)
Wetting agent (non-aqueous)
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diisobutyl Sodium Sulfosuccinate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diisobutyl Sodium Sulfosuccinate by CAS number or substance name.
Studies
2
Lowest NOAEL
750 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Butanedioic acid, sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt
1,4-Bis(2-methylpropyl)sulfobutanyedioate, sodium salt
Butanedioic acid, 2-sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt (1:1)
Succinic acid, sulfo-, 1,4-diisobutyl ester, sodium salt
EINECS 204-839-5
UNII-B51N789L6J
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Softener and conditioner
Wetting agent (non-aqueous)
Foamant
Regulatory Lists
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186667
Frequently Asked Questions
Is Diisobutyl Sodium Sulfosuccinate allowed in the EU?
Diisobutyl Sodium Sulfosuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisobutyl Sodium Sulfosuccinate do in cosmetics?
Diisobutyl Sodium Sulfosuccinate functions as: Surfactant, wetting agent, foam booster, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 127-39-9.
What is the NOAEL for Diisobutyl Sodium Sulfosuccinate?
The NOAEL (No Observed Adverse Effect Level) for Diisobutyl Sodium Sulfosuccinate is =750 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Diisobutyl Sodium Sulfosuccinate used outside cosmetics?
Diisobutyl Sodium Sulfosuccinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diisobutyl Sodium Sulfosuccinate have different safety status in cosmetics vs industrial chemicals?
Diisobutyl Sodium Sulfosuccinate is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Diisobutyl Sodium Sulfosuccinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Alpha-Glucan Oligosaccharide-1
Excellent
Same category
Skin conditioning, cleansing, smoothi...
Ammonium Acryloyl Dimethyltaurate/Carboxyethyl Acrylate Crosspolymer
Excellent
Same category
Dispersing agent (nonsurfactant), vis...
Ammonium Cocoyl Isethionate
Excellent
Same category
Surfactant – cleansing, foaming
Ammonium Lauryl Sulfosuccinate
Excellent
Same category
Cleansing, foaming, surfactant
Ammonium Stearate
Excellent
Same category
Cleansing, surfactant, emulsifying
Apricot Kernel Oil Polyglyceryl-10 Esters
Excellent
Same category
Skin conditioning, emollient, surfact...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
5-Methyl-Beta-Ionone
Good
Chemical family
Fragrance (perfuming)
Alpha-Ionone
Good
Chemical family
Fragrance (Perfuming)
Alpha-Isomethyl Ionone
Good
Chemical family
Fragrance ingredient
Is Diisobutyl Sodium Sulfosuccinate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diisobutyl Sodium Sulfosuccinate in your formulation.