What is the NOAEL for Sodium 1,4-diisobutyl sulfosuccinate?
Sodium 1,4-diisobutyl sulfosuccinate has 10 NOAEL studies in the database. The lowest reported value is 1889.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium 1,4-diisobutyl sulfosuccinate
Also known as: Butanedioic acid, sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt, 1,4-Bis(2-methylpropyl)sulfobutanyedioate, sodium salt, Butanedioic acid, 2-sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt (1:1), Succinic acid, sulfo-, 1,4-diisobutyl ester, sodium salt, EINECS 204-839-5 (+1 more)
CAS 127-39-9
Sodium 1,4-diisobutyl sulfosuccinate (CAS 127-39-9) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Diisobutyl Sodium Sulfosuccinate →
Cross-Vertical Regulatory Divergence
Sodium 1,4-diisobutyl sulfosuccinate is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Sodium 1,4-diisobutyl sulfosuccinate
CAS Number
127-39-9
DTXSID
DTXSID7029164
Molecular Formula
C12H22O7S.Na
InChI Key
NTWXWSVUSTYPJH-UHFFFAOYSA-M
Synonyms
Butanedioic acid, sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt1,4-Bis(2-methylpropyl)sulfobutanyedioate, sodium saltButanedioic acid, 2-sulfo-, 1,4-bis(2-methylpropyl) ester, sodium salt (1:1)Succinic acid, sulfo-, 1,4-diisobutyl ester, sodium saltEINECS 204-839-5UNII-B51N789L6J
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Surfactant (surface active agent)Solubility enhancerSoftener and conditionerWetting agent (non-aqueous)Foamant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1889.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| B51N789L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B51N789L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B51N789L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B51N789L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2772 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6160 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 1,2-diisobutoxycarbonylethanesulphonate | 204-839-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186667
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Sodium 1,4-diisobutyl sulfosuccinate?
Sodium 1,4-diisobutyl sulfosuccinate appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides. Source: EPA CPDat.
Is Sodium 1,4-diisobutyl sulfosuccinate used in cosmetics?
Yes, Sodium 1,4-diisobutyl sulfosuccinate is also indexed as a cosmetic ingredient under the name Diisobutyl Sodium Sulfosuccinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium 1,4-diisobutyl sulfosuccinate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium 1,4-diisobutyl sulfosuccinate have different safety status in cosmetics vs industrial chemicals?
Sodium 1,4-diisobutyl sulfosuccinate is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Sodium 1,4-diisobutyl sulfosuccinate used outside industrial chemicals?
Sodium 1,4-diisobutyl sulfosuccinate also appears in cosmetics, pharmaceutical databases.