Is Diiodomethyltolylsulfone safe in cosmetics?
Diiodomethyltolylsulfone has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Diiodomethyltolylsulfone
Also known as: BRN 2212639, Caswell No. 353B, Diiodomethyl p-tolyl sulfone, 1-((Diiodomethyl)sulfonyl)-4-methylbenzene, EINECS 243-468-3 (+2 more)
INCI: DIIODOMETHYLTOLYLSULFONE
Diiodomethyltolylsulfone (CAS 20018-09-1) is a cosmetic cosmetic ingredient functioning as Preservative (fungicide); antimicrobial agent approved by CFTA/INCI for. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 20018-09-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diiodomethyltolylsulfone is classified GHS Danger (H315, H317, H318, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative (fungicide); antimicrobial agent approved by CFTA/INCI for cosmetic preservation
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(diiodomethylsulfonyl)-4-methylbenzene
InChIKey
XOILGBPDXMVFIP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.1%
US US Status
permitted
US Notes
Permitted — no specific CFR restriction for cosmetics; EPA-registered for industrial use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diiodomethyltolylsulfone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diiodomethyltolylsulfone across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Diiodomethyl p-tolyl a sulfone is classified as an eye corrosive (Toxicity Ca tegory I). For dermal irritation, Diiodomethyl p-tolyl sulfone is a low irritant (Toxicity Category IV) and is not classified as a dermal sensitizer.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diiodomethyltolylsulfone.
Regulatory Flags
potential-allergen
preservative
Known Synonyms
BRN 2212639
Caswell No. 353B
Diiodomethyl p-tolyl sulfone
1-((Diiodomethyl)sulfonyl)-4-methylbenzene
EINECS 243-468-3
EPA Pesticide Chemical Code 101002
UNII-FDJ36QMI3H
Chemical Function
Biocide
Preservative
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1884140
Frequently Asked Questions
Is Diiodomethyltolylsulfone allowed in the EU?
Diiodomethyltolylsulfone EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Diiodomethyltolylsulfone do in cosmetics?
Diiodomethyltolylsulfone functions as: Preservative (fungicide); antimicrobial agent approved by CFTA/INCI for cosmetic preservation. It is classified as a cosmetic ingredient in our database. CAS number: 20018-09-1.
Is Diiodomethyltolylsulfone used outside cosmetics?
Diiodomethyltolylsulfone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diiodomethyltolylsulfone have different safety status in cosmetics vs industrial chemicals?
Diiodomethyltolylsulfone is classified GHS Danger (H315, H317, H318, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Compliance Tools
Check Diiodomethyltolylsulfone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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