What is the NOAEL for Diiodomethyl 4-methylphenyl sulfone?
Diiodomethyl 4-methylphenyl sulfone has 19 NOAEL studies in the database. The lowest reported value is FDJ36QMI3H UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Diiodomethyl 4-methylphenyl sulfone
Also known as: BRN 2212639, Caswell No. 353B, Diiodomethyl p-tolyl sulfone, 1-((Diiodomethyl)sulfonyl)-4-methylbenzene, EINECS 243-468-3 (+2 more)
CAS 20018-09-1
Diiodomethyl 4-methylphenyl sulfone (CAS 20018-09-1) is a chemical substance. Key regulatory status: 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Diiodomethyl 4-methylphenyl sulfone is classified GHS Danger (H315, H317, H318, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
23
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Diiodomethyl 4-methylphenyl sulfone
CAS Number
20018-09-1
DTXSID
DTXSID3032541
Molecular Formula
C8H8I2O2S
InChI Key
XOILGBPDXMVFIP-UHFFFAOYSA-N
Monoisotopic Mass
421.833444
Synonyms
BRN 2212639Caswell No. 353BDiiodomethyl p-tolyl sulfone1-((Diiodomethyl)sulfonyl)-4-methylbenzeneEINECS 243-468-3EPA Pesticide Chemical Code 101002UNII-FDJ36QMI3H
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
21 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FDJ36QMI3H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FDJ36QMI3H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FDJ36QMI3H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FDJ36QMI3H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =20 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =20 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >80 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| >80 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | ToxRefDB_ToxRefDB_v3_pod.csv |
| 10 | mg/kg bw/day | LOAEL | oral | dog | COSMOS_DB |
| 20 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.25 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =5 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =5 | mg/kg bw/day | NEL | oral | rat (sprague dawley; CD(SD)BR) | ToxRefDB_ToxRefDB_v3_pod.csv |
| 2 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1 | % | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =0.125 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =0.5 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =1 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 19 of 19 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1884140
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Diiodomethyl 4-methylphenyl sulfone?
Diiodomethyl 4-methylphenyl sulfone appears on 4 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), active_ingredient; Pesticides, and 1 more. Source: EPA CPDat.
Is Diiodomethyl 4-methylphenyl sulfone used in cosmetics?
Yes, Diiodomethyl 4-methylphenyl sulfone is also indexed as a cosmetic ingredient under the name Diiodomethyltolylsulfone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diiodomethyl 4-methylphenyl sulfone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Diiodomethyl 4-methylphenyl sulfone have different safety status in cosmetics vs industrial chemicals?
Diiodomethyl 4-methylphenyl sulfone is classified GHS Danger (H315, H317, H318, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Is Diiodomethyl 4-methylphenyl sulfone used outside industrial chemicals?
Diiodomethyl 4-methylphenyl sulfone also appears in cosmetics, pharmaceutical databases.