Is Dihydro-alpha-ionone safe in cosmetics?
Dihydro-alpha-ionone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dihydro-alpha-ionone
Also known as: 2-Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, 3,4-Dihydro-α-ionone, EC No.: 250-657-4, EINECS 250-657-4, Dihydro-α-ionone (+6 more)
INCI: DIHYDRO-ALPHA-IONONE
Dihydro-alpha-ionone (CAS 31499-72-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with raspberry, violet, floral, and woody notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 31499-72-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with raspberry, violet, floral, and woody notes
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(2,6,6-trimethylcyclohex-2-en-1-yl)butan-2-one
InChIKey
JHJCHCSUEGPIGE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted with no CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydro-alpha-ionone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
393
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIHYDRO-alpha-IONONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/96 | FAS 42-JECFA 51/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dihydro-alpha-ionone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2-Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-
3,4-Dihydro-α-ionone
EC No.: 250-657-4
EINECS 250-657-4
Dihydro-α-ionone
α-7,8-Dihydroionone
FEMA 3628
BRN 2088879
MFCD00036599
250-657-4
4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4460864
Frequently Asked Questions
Is Dihydro-alpha-ionone allowed in the EU?
Dihydro-alpha-ionone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydro-alpha-ionone do in cosmetics?
Dihydro-alpha-ionone functions as: Fragrance ingredient with raspberry, violet, floral, and woody notes. It is classified as a cosmetic ingredient in our database. CAS number: 31499-72-6.
Is Dihydro-alpha-ionone used outside cosmetics?
Dihydro-alpha-ionone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydro-alpha-ionone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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