What is the NOAEL for 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone?
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone has 7 NOAEL studies in the database. The lowest reported value is 20P9Z50AR5 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone
Also known as: 2-Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, 3,4-Dihydro-α-ionone, EC No.: 250-657-4, EINECS 250-657-4, Dihydro-α-ionone (+6 more)
CAS 31499-72-6
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone (CAS 31499-72-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone
CAS Number
31499-72-6
DTXSID
DTXSID40865599
Molecular Formula
C13H22O
InChI Key
JHJCHCSUEGPIGE-UHFFFAOYSA-N
Monoisotopic Mass
194.167065
Synonyms
2-Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3,4-Dihydro-α-iononeEC No.: 250-657-4EINECS 250-657-4Dihydro-α-iononeα-7,8-DihydroiononeFEMA 3628BRN 2088879MFCD00036599250-657-44-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 20P9Z50AR5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20P9Z50AR5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20P9Z50AR5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20P9Z50AR5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)butan-2-one | 250-657-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL4460864
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone?
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone used in cosmetics?
Yes, 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone is also indexed as a cosmetic ingredient under the name Dihydro-alpha-ionone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone used outside industrial chemicals?
4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-butanone also appears in cosmetics, pharmaceutical databases.