Is Dihexyl Fumarate safe in cosmetics?
Dihexyl Fumarate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dihexyl Fumarate
Also known as: 2-Butenedioic acid, dihexyl ester, (2E)-, 2-Butenedioic acid (2E)-, 1,4-dihexyl ester, 2-Butenedioic acid (2E)-, dihexyl ester, 2-Butenedioic acid (E)-, dihexyl ester, Fumaric acid, dihexyl ester (+1 more)
INCI: DIHEXYL FUMARATE
Dihexyl Fumarate (CAS 19139-31-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 19139-31-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dihexyl Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dihexyl (E)-but-2-enedioate
InChIKey
QMCVOSQFZZCSLN-VAWYXSNFSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no CFR prohibition or restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihexyl Fumarate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dihexyl Fumarate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihexyl Fumarate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dihexyl Fumarate.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dihexyl Fumarate by CAS number or substance name.
Studies
4
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Butenedioic acid, dihexyl ester, (2E)-
2-Butenedioic acid (2E)-, 1,4-dihexyl ester
2-Butenedioic acid (2E)-, dihexyl ester
2-Butenedioic acid (E)-, dihexyl ester
Fumaric acid, dihexyl ester
EINECS No.: 242-833-4
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3247954
Frequently Asked Questions
Is Dihexyl Fumarate allowed in the EU?
Dihexyl Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihexyl Fumarate do in cosmetics?
Dihexyl Fumarate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 19139-31-2.
What is the NOAEL for Dihexyl Fumarate?
The NOAEL (No Observed Adverse Effect Level) for Dihexyl Fumarate is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dihexyl Fumarate used outside cosmetics?
Dihexyl Fumarate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dihexyl Fumarate have different safety status in cosmetics vs industrial chemicals?
Dihexyl Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications.
Compliance Tools
Check Dihexyl Fumarate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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