NOAEL Studies Cosmetic Ingredient

Dihexyl Fumarate NOAEL Studies

INCI: DIHEXYL FUMARATE

CAS: 19139-31-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5951; Record_ID=skin_sensitization_invivo_1367; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID00893393; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80083-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID00893393
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5948; Record_ID=skin_sensitization_invivo_1367; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID00893393; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80083-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID00893393
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5955; Record_ID=skin_sensitization_invivo_1367; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID00893393; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80083-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID00893393
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral subchronic; 5 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadbbe4b0a7c65d1c5bb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27510/7/6/2?documentUUID=1e1d32d0-d151-4c5d-a9b6-967766498188; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=clinical biochemistry|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECHA IUCLID:15843825:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6684d5c94968d0abbf455515de5b6635
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6B3O343SS2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6B3O343SS2"}
openFDA substances FDA UNII substance identifier 6B3O343SS2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6B3O343SS2"}
openFDA substances FDA UNII substance identifier 6B3O343SS2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6B3O343SS2"}
openFDA substances FDA UNII substance identifier 6B3O343SS2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H28O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6B3O343SS2"}