Is Diethylene Glycol Dibenzoate safe in cosmetics?
Diethylene Glycol Dibenzoate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Diethylene Glycol Dibenzoate
Also known as: Ethanol, 2,2'-oxybis-, dibenzoate, 4-09-00-00356, Benzo Flex 2-45, Benzoic acid, diester with diethylene glycol, Benzoyloxyethoxyethyl benzoate (+4 more)
INCI: DIETHYLENE GLYCOL DIBENZOATE
Diethylene Glycol Dibenzoate (CAS 120-55-8) is a cosmetic cosmetic ingredient functioning as Plasticizer, solvent, perfume stabilizer. Reported NOAEL 414 mg/kg bw/day in dog (COSMOS_DB); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 120-55-8 →
Auto-generated CPSR Part A draft with source citations
Function
Plasticizer, solvent, perfume stabilizer
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-benzoyloxyethoxy)ethyl benzoate
InChIKey
NXQMCAOPTPLPRL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — TSCA listed; FDA-listed as indirect food contact substance; no 21 CFR cosmetic prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylene Glycol Dibenzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Diethylene Glycol Dibenzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 414 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | =75 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0447
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Plasticizer
Softener and conditioner
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diethylene Glycol Dibenzoate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethylene Glycol Dibenzoate by CAS number or substance name.
Studies
3
Lowest NOAEL
75 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Ethanol, 2,2'-oxybis-, dibenzoate
4-09-00-00356
Benzo Flex 2-45
Benzoic acid, diester with diethylene glycol
Benzoyloxyethoxyethyl benzoate
BRN 2509507
Dibenzoyldiethyleneglycol ester
EINECS 204-407-6
UNII-YAI66YDY1C
Chemical Function
Softener and conditioner
Plasticizer
Binder
Regulatory Lists
Europe; plastic_additive
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2130591
Frequently Asked Questions
Is Diethylene Glycol Dibenzoate allowed in the EU?
Diethylene Glycol Dibenzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylene Glycol Dibenzoate do in cosmetics?
Diethylene Glycol Dibenzoate functions as: Plasticizer, solvent, perfume stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 120-55-8.
What is the NOAEL for Diethylene Glycol Dibenzoate?
The NOAEL (No Observed Adverse Effect Level) for Diethylene Glycol Dibenzoate is 414 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Diethylene Glycol Dibenzoate used outside cosmetics?
Diethylene Glycol Dibenzoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethylene Glycol Dibenzoate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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