NOAEL Studies Cosmetic Ingredient

Diethylene Glycol Dibenzoate NOAEL Studies

INCI: DIETHYLENE GLYCOL DIBENZOATE

CAS: 120-55-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 1 % rat oral 90 day Subchronic FAP; Ninety Day Toxicity Study in Rats
COSMOS_DB NOAEL 414 mg/kg bw/day dog oral 90 day Subchronic FAP; Ninety Day Toxicity Study in Dogs
NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2830 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1623; row=839; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol dibenzoate; preferred_name=Diethylene glycol dibenzoate; dtxsid=DTXSID0026967; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3535 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_1625; row=838; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol dibenzoate; preferred_name=Diethylene glycol dibenzoate; dtxsid=DTXSID0026967; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4190 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_1626; row=837; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol dibenzoate; preferred_name=Diethylene glycol dibenzoate; dtxsid=DTXSID0026967; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4843 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_1593; row=836; data_type=In Vivo; mixture=Chemical; chemical_name=Diethylene glycol dibenzoate; preferred_name=Diethylene glycol dibenzoate; dtxsid=DTXSID0026967; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 843 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=245; Record_ID=adme_parameters_972; Data_Type=Measured; DTXSID=DTXSID0026967; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=843.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7960; RecordID=ARPathway2016_671; DatasetName=ARPathway2016; DTXSID=DTXSID0026967; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026967
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =75 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/3?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820904_15823438:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9369fdd5f30e9aece1c86a6495947a69
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/3?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15823475:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2998dab2b12b36f7cfeb9884acd39e34
ToxValDB_ECHA_IUCLID NOAEL =10000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d219627; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/2?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15859155:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_476d7b243bacfecc6666d5bf2dabbae3
ToxValDB_ECHA_IUCLID NOEL =375 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f3dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/3?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820904_15823438:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a8ebd354121d4d3e28c50feb1745b93
ToxValDB_ECHA_IUCLID NOEL =444 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1da0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/6/2?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15850492:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be2d4b169a76c5e6d49cd2642f6c9a4a
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/3?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15823660:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cb1e5510348a056de8685d426e59f451
ToxValDB_ECHA_IUCLID NOEL =3300 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d219627; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/9/2?documentUUID=c425cfe1-8a7b-43f2-96d6-e831dee59048; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID:15860211:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35063b68a5f5abf4f78b49937382a1b0
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.8 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630048:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_784558e63fd8cfc20fc9ef8a8fb5b0cf
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =3300 ppm Rat oral chronic; 38 weeks developmental LONG_REF=Benzoflex 2-45. Study of Reproductive Performance in CD Rats Treated Continuously through Two Successive Generations by Dietary Administration.Huntingdon Life Sciences. 2001.; TITLE=Benzoflex 2-45. Study of Reproductive Performance in CD Rats Treated Continuously through Two Successive Generations by Dietary Administration; AUTHOR=Huntingdon Life Sciences; QUALITY=1; EXTERNAL_SOURCE_ID=66228; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=HPVIS:15643427:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50ad668b22d8419982a9864bcecc800a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier YAI66YDY1C UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H18O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YAI66YDY1C"}
openFDA substances FDA UNII substance identifier YAI66YDY1C UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H18O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YAI66YDY1C"}
openFDA substances FDA UNII substance identifier YAI66YDY1C UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H18O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YAI66YDY1C"}
openFDA substances FDA UNII substance identifier YAI66YDY1C UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H18O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YAI66YDY1C"}