What is the NOAEL for Diethylene glycol dibenzoate?
Diethylene glycol dibenzoate has 21 NOAEL studies in the database. The lowest reported value is 5.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethylene glycol dibenzoate
Also known as: Ethanol, 2,2'-oxybis-, dibenzoate, 4-09-00-00356, Benzo Flex 2-45, Benzoic acid, diester with diethylene glycol, Benzoyloxyethoxyethyl benzoate (+4 more)
CAS 120-55-8
Diethylene glycol dibenzoate (CAS 120-55-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Diethylene Glycol Dibenzoate →
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Diethylene glycol dibenzoate
CAS Number
120-55-8
DTXSID
DTXSID0026967
Molecular Formula
C18H18O5
InChI Key
NXQMCAOPTPLPRL-UHFFFAOYSA-N
Monoisotopic Mass
314.115424
Synonyms
Ethanol, 2,2'-oxybis-, dibenzoate4-09-00-00356Benzo Flex 2-45Benzoic acid, diester with diethylene glycolBenzoyloxyethoxyethyl benzoateBRN 2509507Dibenzoyldiethyleneglycol esterEINECS 204-407-6UNII-YAI66YDY1C
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes and skin. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
Softener and conditionerPlasticizerBinderUV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 843 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =5.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| YAI66YDY1C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YAI66YDY1C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YAI66YDY1C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YAI66YDY1C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2830 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3535 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4190 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4843 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1 | % | LOAEL | oral | rat | COSMOS_DB |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =75 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 414 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3300 | ppm | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =10000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =375 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =444 | mg/kg bw/day | NOEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3300 | ppm | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Oxydiethylene dibenzoate | 204-407-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2130591
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Diethylene glycol dibenzoate?
Diethylene glycol dibenzoate appears on 4 regulatory/inventory lists including Europe; plastic_additive, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Is Diethylene glycol dibenzoate used in cosmetics?
Yes, Diethylene glycol dibenzoate is also indexed as a cosmetic ingredient under the name Diethylene Glycol Dibenzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethylene glycol dibenzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethylene glycol dibenzoate used outside industrial chemicals?
Diethylene glycol dibenzoate also appears in cosmetics, pharmaceutical databases.