Good UV Filter / Sunscreen NOAEL Data SCCS/CIR Reviewed Sensitization Data

Diethylamino Hydroxybenzoyl Hexyl Benzoate

Also known as: UNII-ANQ870JD20, Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester, Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate, Uvinul A Plus

INCI: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE

Diethylamino Hydroxybenzoyl Hexyl Benzoate (CAS 302776-68-7) is a cosmetic uv filter / sunscreen functioning as Broad-spectrum UVA organic UV filter; photostable UVA absorber; supports. NOAEL 166 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 10%; 3 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 302776-68-7 →

Auto-generated CPSR Part A draft with source citations
CAS Number
302776-68-7
View industrial chemical safety profile →
Function
Broad-spectrum UVA organic UV filter; photostable UVA absorber; supports water-resistance and critical wavelength maintenance after immersion
Safety Rating
GOOD

Chemistry & Identifiers

EC Number
443-860-6
ChEBI: CHEBI:136006 UNII: ANQ870JD20 Wikidata: Q5275146

Regulatory Status

EU EU Status permitted
EU Max Conc. 10%
US US Status restricted
US Notes FDA proposed order December 2025 to add as OTC sunscreen active at ≤6%. First new OTC sunscreen active ingredient in over 25 years. Not yet available on US market pending final rule under CARES Act / OTC Monograph M020.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylamino Hydroxybenzoyl Hexyl Benzoate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Diethylamino Hydroxybenzoyl Hexyl Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL =200 mg/kg bw/day oral - developmental toxicity SCCNFP_vision_codex
NOAEL =200 mg/kg oral rat NOAEL study SCCNFP_vision_codex
NOAEL =200 mg/kg bw/day oral - developmental toxicity SCCNFP_vision_codex
NOAEL =200 mg/kg oral rat NOAEL study SCCNFP_vision_codex
NOAEL =200 mg/kg bw/day oral - developmental toxicity SCCNFP_vision_codex
NOAEL =200 mg/kg oral rat NOAEL study SCCNFP_vision_codex
NOAEL =200 mg/kg bw/day oral - developmental toxicity SCCNFP_vision_codex
NOAEL =200 mg/kg oral rat NOAEL study SCCNFP_vision_codex
NOAEL =1350 mg/kg bw oral rat NOAEL study SCCNFP_vision_codex

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

sccs SCCS/1678/25 26 June 2025
Verdict: unknown
NOAEL: 5 mg/kg bw/d (not specified)
Max Concentration: 10% in general
sccs SCCS/1678/25 26 June 2025
Verdict: unknown
NOAEL: 2.5 mg/kg bw/d (oral)
Max Concentration: 10% in general
sccs SCCS/1678/25 26 June 2025
Verdict: unknown
NOAEL: 5 mg/kg bw/d (oral)
Max Concentration: 10% in general

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Diethylamino Hydroxybenzoyl Hexyl Benzoate across SCCS product categories, with measured dermal absorption where available.

Sensitization Profile

Contact sensitization data for Diethylamino Hydroxybenzoyl Hexyl Benzoate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
photosensitivity

Source: SCCS

EPA ToxValDB — Toxicity Values

10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LD50 >2000 mg/kg Rat oral - ECHA IUCLID
LD50 >2000 mg/kg Rat oral - ECHA IUCLID
LOEL =100 mg/kg-day Rat oral - ECHA IUCLID
NOAEL >=1000 mg/kg-day Rat oral - ECHA IUCLID
NOAEL =200 mg/kg-day Rat oral - ECHA IUCLID
NOAEL >=1440 mg/kg-day Rat oral subchronic ECHA IUCLID
NOAEL =100 mg/kg-day Rat oral - ECHA IUCLID
NOAEL =300 mg/kg-day Rat oral - ECHA IUCLID
NOAEL =100 mg/kg-day Rat oral - ECHA IUCLID
NOAEL =300 mg/kg-day Rat oral - ECHA IUCLID

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα (limited)
LOEC: 10 µM
EU status: allowed (max 10%)

weak modulator

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex VI — Permitted UV Filters
Max: 10%

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 10.0
Korea (Restricted): max 10%
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (3)
Jurisdiction Status Max % Product Type
CN permitted_uv_filter 10 All cosmetics
IN permitted_uv_filter 10.0 sunscreen products only
BR permitted_uv_filter 10 Sunscreen products

Expanded Dermal Absorption Data

Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.

Aggregated DA Values (3 records across 5 sources)
Type DA % Method Skin Model SCCS Ref
default 5.0 method=default - -
default 18.0 method=default - -
default 50.0 method=default - -

Typical Use Concentrations

Reported concentration ranges per product category from SCCS/CIR/industry sources.

Product Category Typical Range Max Reported Source
Sunscreen 1–10 10 SCCS

Additional Ingredient Properties

4 property records from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "other", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "photosensitivity", "ifra_restricted": "no", "source": "SCCS"}
anti_pollution
{"cas_number": "302776-68-7", "ingredient_class": "blue_light_filter", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "blue_light_HEV/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulat…
baby_pediatric
{"cas_number": "302776-68-7", "ingredient_class": "sunscreen_baby", "pediatric_safety_rating": "acceptable", "minimum_age_months": "12", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Uvinul A Plus", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Sunsc…
sunscreen_uv
{"cas_number": "302776-68-7", "uv_filter_type": "organic_UVA", "chemical_class": "other", "absorption_spectrum_nm_range": "340-400", "peak_absorption_wavelength_nm": "354", "molar_extinction_coefficient": "63000", "critical_wavelength_nm": "384", "UVA_PF": "25-40", "SPF_contribution_per_percent": "3.2", "photostability_rating": "photostable", "photodegradation_half_life_hours": ">24", "photostabil…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Fragrance UV stabilizer
Regulatory List Membership (3)
EU Regulated in Personal Care IFRA Fragrance Transparency List EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for Diethylamino Hydroxybenzoyl Hexyl Benzoate.

Regulatory Flags

uva-filter broad-spectrum photostable water-resistant fda-pending-2025 eu-permitted new-us-approval ifra_fragrance eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Diethylamino Hydroxybenzoyl Hexyl Benzoate by CAS number or substance name.

Studies
80
Lowest NOAEL
0.025
Highest NOAEL
2000

Units vary across source rows: mg/kg bw/d, mg/kg, mg/kg bw/day

SCCS_vision_codex ToxValDB_ECHA_IUCLID COSMOS_DB SCCNFP_vision_codex

Dermal Absorption

View details ->
Absorption % Method Vehicle
5.0 method=default -
18.0 method=default -
50.0 method=default -

Known Synonyms

UNII-ANQ870JD20 Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate Uvinul A Plus

Chemical Function

UV stabilizer Fragrance

Regulatory Lists

Europe; Personal care IFRA Transparency Canada; pharmaceutical

Australian Status

AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of cosmetic products at concentrations no more than 10%.

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
diethylamino hydroxybenzoyl hexyl benzoate
View full pharmaceutical profile →

Frequently Asked Questions

Is Diethylamino Hydroxybenzoyl Hexyl Benzoate safe in cosmetics?

Diethylamino Hydroxybenzoyl Hexyl Benzoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.

Is Diethylamino Hydroxybenzoyl Hexyl Benzoate allowed in the EU?

Diethylamino Hydroxybenzoyl Hexyl Benzoate EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylamino Hydroxybenzoyl Hexyl Benzoate do in cosmetics?

Diethylamino Hydroxybenzoyl Hexyl Benzoate functions as: Broad-spectrum UVA organic UV filter; photostable UVA absorber; supports water-resistance and critical wavelength maintenance after immersion. It is classified as a UV Filter / Sunscreen in our database. CAS number: 302776-68-7.

What is the NOAEL for Diethylamino Hydroxybenzoyl Hexyl Benzoate?

The NOAEL (No Observed Adverse Effect Level) for Diethylamino Hydroxybenzoyl Hexyl Benzoate is 200 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is Diethylamino Hydroxybenzoyl Hexyl Benzoate used outside cosmetics?

Diethylamino Hydroxybenzoyl Hexyl Benzoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

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