Is Dibutyl Maleate safe in cosmetics?
Dibutyl Maleate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dibutyl Maleate
Also known as: Dibutyl (2Z)-but-2-enedioate, 2-Butenedioic acid (2Z)-, 1,4-dibutyl ester, BRN 1726634, 2-Butenedioic acid, dibutyl ester, Butyl maleate (+7 more)
INCI: DIBUTYL MALEATE
Dibutyl Maleate (CAS 105-76-0) is a cosmetic cosmetic ingredient functioning as Plasticizer, comonomer intermediate. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 105-76-0 →
Auto-generated CPSR Part A draft with source citations
Function
Plasticizer, comonomer intermediate
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dibutyl (Z)-but-2-enedioate
InChIKey
JBSLOWBPDRZSMB-FPLPWBNLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not listed as a cosmetic ingredient; no specific CFR entry; industrial chemical
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibutyl Maleate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dibutyl Maleate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Plasticizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dibutyl Maleate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dibutyl Maleate by CAS number or substance name.
Studies
15
Lowest NOAEL
55 mg/kg bw/day
Highest NOAEL
5654 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Dibutyl (2Z)-but-2-enedioate
2-Butenedioic acid (2Z)-, 1,4-dibutyl ester
BRN 1726634
2-Butenedioic acid, dibutyl ester
Butyl maleate
DBM (VAN)
EINECS 203-328-4
NSC 6711
RC Comonomer DBM
Staflex DBM
Dibutylester kyseliny maleinove
UNII-4X371TMK9K
Chemical Function
Fragrance
Plasticizer
Regulatory Lists
Indirect additives food contact (10/2018)
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1466826
Frequently Asked Questions
Is Dibutyl Maleate allowed in the EU?
Dibutyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Maleate do in cosmetics?
Dibutyl Maleate functions as: Plasticizer, comonomer intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 105-76-0.
Is Dibutyl Maleate used outside cosmetics?
Dibutyl Maleate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dibutyl Maleate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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