What is the NOAEL for Dibutyl maleate?
Dibutyl maleate has 6 NOAEL studies in the database. The lowest reported value is 5.28 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dibutyl maleate
Also known as: Dibutyl (2Z)-but-2-enedioate, 2-Butenedioic acid (2Z)-, 1,4-dibutyl ester, BRN 1726634, 2-Butenedioic acid, dibutyl ester, Butyl maleate (+7 more)
CAS 105-76-0
Dibutyl maleate (CAS 105-76-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Dibutyl maleate
CAS Number
105-76-0
DTXSID
DTXSID3026724
Molecular Formula
C12H20O4
InChI Key
JBSLOWBPDRZSMB-FPLPWBNLSA-N
Monoisotopic Mass
228.136159
Synonyms
Dibutyl (2Z)-but-2-enedioate2-Butenedioic acid (2Z)-, 1,4-dibutyl esterBRN 17266342-Butenedioic acid, dibutyl esterButyl maleateDBM (VAN)EINECS 203-328-4NSC 6711RC Comonomer DBMStaflex DBMDibutylester kyseliny maleinoveUNII-4X371TMK9K
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragrancePlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.28 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4X371TMK9K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X371TMK9K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X371TMK9K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4X371TMK9K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dibutyl maleate | 203-328-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1466826
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Dibutyl maleate?
Dibutyl maleate appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Dibutyl maleate used in cosmetics?
Yes, Dibutyl maleate is also indexed as a cosmetic ingredient under the name Dibutyl Maleate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibutyl maleate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Dibutyl maleate used outside industrial chemicals?
Dibutyl maleate also appears in cosmetics, pharmaceutical databases.