Is Dibenzyl Ether safe in cosmetics?
Dibenzyl Ether has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dibenzyl Ether
Also known as: 1,1-[Oxybis(methylene)]bisbenzene, 1,1'-(Oxydimethanediyl)dibenzene, 4-06-00-02240, BA (VAN), BRN 1911156 (+9 more)
INCI: DIBENZYL ETHER
Dibenzyl Ether (CAS 103-50-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 103-50-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
phenylmethoxymethylbenzene
InChIKey
MHDVGSVTJDSBDK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibenzyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
11.38%
DPRA Lys %
0%
KeratinoSens IC50
244 µM
hCLAT CV75
150 µg/mL
LLNA EC3
6.3%
NESIL
2592 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: personal communication by RIFM (RIFM DB #52907); DPRA: Hoffmann et al., 2018; KS: No reference provided in NICEATM database; hCLAT: No reference provided in NICEATM database; HPPT: [33] Kligman AM (1974): Report to RIFM, 4 June, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 108 | 0 | 2362 | 2362 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.26% | 7a (Deodorant – not spray) | 0.52% |
| 2 (Body spray) | 0.078% | 7b (Deodorant spray) | 0.52% |
| 3 (Body cream) | 0.26% | 8 (Face cream) | 0.086% |
| 4 (Fine fragrance) | 1.0% | 9 (Soap) | 1.3% |
| 5a (Body lotion) | 0.26% | 10a (Household – non-spray) | 1.3% |
| 5b (Face cream leave-on) | 0.26% | 10b (Household – spray) | No Restriction% |
| 5c (Hand cream) | 0.26% | 11a (Intimate – leave-on) | 0.086% |
| 5d (Baby cream) | 0.086% | 11b (Intimate – rinse) | 0.086% |
| 6 (Mouthwash) | 0.26% | 12 (Not for consumer exposure) | No Restriction% |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1256
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYL ETHER | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Plasticizer
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dibenzyl Ether.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dibenzyl Ether by CAS number or substance name.
Studies
21
Lowest NOAEL
175 mg/kg bw/day
Highest NOAEL
1400 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
1,1-[Oxybis(methylene)]bisbenzene
1,1'-(Oxydimethanediyl)dibenzene
4-06-00-02240
BA (VAN)
BRN 1911156
EINECS 203-118-2
Ether, dibenzyl
FEMA No. 2371
FEMA Number 2371
1,1-Oxybismethylene, bis benzene
1,1'-(Oxybis(methylene))bisbenzene
Plasticator BA
UNII-2O6CNO27RJ
[(benzyloxy)methyl]benzene
Chemical Function
Fragrance
Flavouring and nutrient
Plasticizer
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL152299
Frequently Asked Questions
Is Dibenzyl Ether allowed in the EU?
Dibenzyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibenzyl Ether do in cosmetics?
Dibenzyl Ether functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-50-4.
Is Dibenzyl Ether used outside cosmetics?
Dibenzyl Ether also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dibenzyl Ether compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Acetaminophen
Moderate
Chemical family
Skin conditioning; primarily a pharma...
Acetanilid
Poor
Chemical family
Historical antipyretic/analgesic; no ...
Benzyl Butyrate
Good
Chemical family
Perfuming / Fragrance ingredient
Is Dibenzyl Ether in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dibenzyl Ether in your formulation.