NOAEL Studies Cosmetic Ingredient

Dibenzyl Ether NOAEL Studies

INCI: DIBENZYL ETHER

CAS: 103-50-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 196 mg/kg bw/day rat oral 91 day Subchronic PAFA; FOOD CHEM TOXICOL 30:559-566
COSMOS_DB NOAEL 3.33 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 620 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 62 mg/kg bw/day rat oral 91 day Subchronic PAFA; FOOD CHEM TOXICOL 30:559-566
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_338; row=8913; data_type=In Vivo; mixture=Chemical; chemical_name=Dibenzyl ether; preferred_name=Dibenzyl ether; dtxsid=DTXSID5025819; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025819; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 65.83 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1801; Record_ID=skin_sensitization_invitro_466; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=65.83; Reported_Response_Unit=ug/mL; Response=65.83; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization CV75 150 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1803; Record_ID=skin_sensitization_invitro_466; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=h-CLAT; Endpoint=CV75; Reported_Response=150; Reported_Response_Unit=ug/mL; Response=150; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization EC1.5 37.78 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4108; Record_ID=skin_sensitization_invitro_936; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=37.78; Reported_Response_Unit=uM; Response=37.78; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization EC3 1136 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4110; Record_ID=skin_sensitization_invitro_936; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=1135.6600000000001; Reported_Response_Unit=uM; Response=1136; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization IC50 244 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4112; Record_ID=skin_sensitization_invitro_936; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=244; Reported_Response_Unit=uM; Response=244; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization Imax 3.37 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4114; Record_ID=skin_sensitization_invitro_936; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.37; Reported_Response_Unit=Unitless; Response=3.37; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2131; Record_ID=skin_sensitization_invivo_619; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80080-7|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2129; Record_ID=skin_sensitization_invivo_619; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80080-7|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2136; Record_ID=skin_sensitization_invivo_619; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025819; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80080-7|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025819; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025819
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =43.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631011:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42c072e58ea695915360b8dc5f9f8208
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2O6CNO27RJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H14O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2O6CNO27RJ"}
openFDA substances FDA UNII substance identifier 2O6CNO27RJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H14O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2O6CNO27RJ"}
openFDA substances FDA UNII substance identifier 2O6CNO27RJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H14O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2O6CNO27RJ"}
openFDA substances FDA UNII substance identifier 2O6CNO27RJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H14O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2O6CNO27RJ"}