Poor Cosmetic Ingredient GHS Classified

Deltamethrin

Also known as: Deltamethrin [BSI:ISO], (S)-alpha-Cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropan-1-carboxylate, (S)-alpha-Cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate, (S)-alpha-Cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropane carboxyate, (1R-(1alpha(S*),3alpha))-Cyano(3-phenoxyphenyl)methyl 3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate (+9 more)

INCI: DELTAMETHRIN

Deltamethrin (CAS 52918-63-5) is a cosmetic cosmetic ingredient functioning as Synthetic pyrethroid insecticide/pesticide. EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 52918-63-5 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Deltamethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H331, H410, H400, H300).

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

52918-63-5

View industrial chemical safety profile →

Function

Synthetic pyrethroid insecticide/pesticide

Safety Rating

POOR

Chemistry & Identifiers

Formula

C22H19Br2NO3

505.2 g/mol

PubChem CID

40585

IUPAC Name

trans-[(S)-cyano-(3-phenoxyphenyl)methyl] (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane-1-carboxylate

InChIKey

OWZREIFADZCYQD-NSHGMRRFSA-N

ChEBI: CHEBI:4388 UNII: 2JTS8R821G Wikidata: Q422257

Regulatory Status

EU EU Status prohibited

US US Status prohibited

US Notes Not permitted for cosmetic use. Regulated as a pesticide under FIFRA/EPA; not approved for cosmetic application.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Deltamethrin.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

SkullToxicCancerHealth hazEnviroAqua

Hazard Statements

Toxic if swallowed or if inhaled Causes mild skin irritation Causes eye irritation Causes damage to central nervous system May cause respiratory irritation Very toxic to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed. Exposure through the skin could cause local effects, including sensations such as tingling, itching or burning.

Routes of Exposure

The substance can be absorbed into the body by inhalation and by ingestion.

IARC Carcinogenicity

International Agency for Research on Cancer (WHO) monograph evaluation.

IARC Group

Volume

Evaluation Year

1990

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Acute ToxicityEnvironmental Hazard

Hazard Class and Category

Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1

Hazard Statements

H331 Toxic if inhaled
H301 Toxic if swallowed
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects

Specific Concentration Limits / M-factors

M = 1000000

Inserted via ATP: ATP01

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Suspected Evidence: Moderate (2019)

Health effects: Yes

Affected pathways: Estrogenic, Thyroid

Regulatory framework: Cosmetics

Source list: II

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (5)

Carcinogen Classification

3, not classifiable as to its carcinogenicity to humans. (L135)

Source: Toxin and Toxin Target Database (T3DB)

Carcinogen Classification

Deltamethrin | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 53: (1991) Occupational Exposures in Insecticide Application, and Some Pesticides

Source: International Agency for Research on Cancer (IARC)

Evidence for Carcinogenicity

Cancer Classification: Not Likely to be Carcinogenic to Humans | Evaluation: No data were available from studies in humans. There is inadequate evidence for the carcinogenicity of deltamethrin in experimental animals. Overall evaluation: Deltamethrin is not classifiable as to its carcinogenicity to humans (Group 3).

Source: Hazardous Substances Data Bank (HSDB)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

ICSC Safety Card

0247

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Regulatory (3)

JECFA Evaluation

DECAMETHRIN | 2003 | 0-0.01 mg/kg bw | JMPR established an ADI of 0–0.01 mg/kg bw for deltamethrin based on NOAELs of 1 mg/kg bw/d in a 1-year study in dogs treated by capsule, a 2-year study in dogs treated in the diet, and two 2-year studies in rats treated in the diet, with a safety factor of 100. The Meeting established an acute RfD of 0.05 mg/kg bw based on the NOAEL of 5 mg/kg bw acute neuro

Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

JECFA Evaluation

DELTAMETHRIN | 2003 | 0-0.01 mg/kg bw | JMPR established an ADI of 0–0.01 mg/kg bw for deltamethrin based on NOAELs of 1 mg/kg bw/d in a 1-year study in dogs treated by capsule, a 2-year study in dogs treated in the diet, and two 2-year studies in rats treated in the diet, with a safety factor of 100. The Meeting established an acute RfD of 0.05 mg/kg bw based on the NOAEL of 5 mg/kg bw acute neur

Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

JECFA Evaluation

RU 22974 | 2003 | 0-0.01 mg/kg bw | JMPR established an ADI of 0–0.01 mg/kg bw for deltamethrin based on NOAELs of 1 mg/kg bw/d in a 1-year study in dogs treated by capsule, a 2-year study in dogs treated in the diet, and two 2-year studies in rats treated in the diet, with a safety factor of 100. The Meeting established an acute RfD of 0.05 mg/kg bw based on the NOAEL of 5 mg/kg bw acute neurotox

Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Biocide No specific technical function

Expert Verdict

Expert safety assessment and concern-level summary for Deltamethrin.

Regulatory Flags

endocrine_disruptor

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Deltamethrin by CAS number or substance name.

Studies

Lowest NOAEL

Highest NOAEL

1000

Units vary across source rows: mg/kg bw/day, mg/kg bw

INCHEM_WHO_jmpr_jmpmono_v00pr04

Known Synonyms

Deltamethrin [BSI:ISO] (S)-alpha-Cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropan-1-carboxylate (S)-alpha-Cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate (S)-alpha-Cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropane carboxyate (1R-(1alpha(S*),3alpha))-Cyano(3-phenoxyphenyl)methyl 3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate Dekametrin Deltamethrine 3-(2,2-Dibromoethenyl)-2,2-dimethylcyclopropanecarboxylic acid, cyano(3-phenoxy-phenyl)-, methyl ester EINECS 258-256-6 Esbecythrin Stricker EPA Pesticide Chemical Code 978051 Deltametryna UNII-2JTS8R821G

Chemical Function

Biocide

Regulatory Lists

active_ingredient; agricultural; applied; Pesticides active_ingredient; Europe; Pesticides agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; grain; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue agricultural; detected; fruits_and_vegetables; Pesticides; residue

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

DELTAMETHRIN

ChEMBL ID

CHEMBL1593566

Max Phase

-1

Adverse Event Associations

View full pharmaceutical profile →

Frequently Asked Questions

Is Deltamethrin safe in cosmetics?

Deltamethrin has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.

Is Deltamethrin allowed in the EU?

Deltamethrin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Deltamethrin do in cosmetics?

Deltamethrin functions as: Synthetic pyrethroid insecticide/pesticide. It is classified as a cosmetic ingredient in our database. CAS number: 52918-63-5.

Is Deltamethrin classified as hazardous under GHS?

Deltamethrin carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed or if inhaled Causes mild skin irritation Causes eye irritation Causes damage to central nervous system May cause respiratory irritation Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is Deltamethrin used outside cosmetics?

Deltamethrin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Deltamethrin have different safety status in cosmetics vs industrial chemicals?

Deltamethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H331, H410, H400, H300).

Compliance Tools

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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