Danger GHS06GHS09 NOAEL Data IARC Group 3 Cosmetic Ingredient

Deltamethrin

Also known as: Deltamethrin [BSI:ISO], (S)-alpha-Cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropan-1-carboxylate, (S)-alpha-Cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate, (S)-alpha-Cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropane carboxyate, (1R-(1alpha(S*),3alpha))-Cyano(3-phenoxyphenyl)methyl 3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate (+9 more)

CAS 52918-63-5

Deltamethrin (CAS 52918-63-5) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H301; H400; H410. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ILO ICSC.

View cosmetic safety profile for Deltamethrin →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
60
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
Deltamethrin
CAS Number
52918-63-5
DTXSID
DTXSID8020381
Molecular Formula
C22H19Br2NO3
InChI Key
OWZREIFADZCYQD-NSHGMRRFSA-N
Monoisotopic Mass
502.973169
Synonyms
Deltamethrin [BSI:ISO](S)-alpha-Cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropan-1-carboxylate(S)-alpha-Cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate(S)-alpha-Cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropane carboxyate(1R-(1alpha(S*),3alpha))-Cyano(3-phenoxyphenyl)methyl 3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylateDekametrinDeltamethrine3-(2,2-Dibromoethenyl)-2,2-dimethylcyclopropanecarboxylic acid, cyano(3-phenoxy-phenyl)-, methyl esterEINECS 258-256-6EsbecythrinStrickerEPA Pesticide Chemical Code 978051

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable199053

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1H331; H301; H400; H410GHS06; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsToxic if swallowed or if inhaled Causes mild skin irritation Causes eye irritation Causes damage to central nervous system May cause respiratory irritation Very toxic to aquatic life with long lasting effects
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed. Exposure through the skin could cause local effects, including sensations such as tingling, itching or burning.
Routes of ExposureThe substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 38 records
BiocideNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records
ListKeywordSource
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; grain; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
active_ingredient; agricultural; PesticidesArizona Department of Environmental QualityState of Arizona

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
<=0.01mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
=0.01mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.01mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.01mg/kg bwARfD-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.01mg/kg bwARfD-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
7uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
3unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
4unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
=2UnitlessEPA classificationoralRat (Male)NTP_ICE_acute_oral
=2UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
2unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
3unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
3unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
4unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
=4UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
4unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
2JTS8R821GUNIIFDA UNII substance identifier--openFDA substances
2JTS8R821GUNIIFDA UNII substance identifier--openFDA substances
2JTS8R821GUNIIFDA UNII substance identifier--openFDA substances
2JTS8R821GUNIIFDA UNII substance identifier--openFDA substances
0.01fractionFu-HumanNTP_ICE_adme_parameters
0.049fractionFu-RatNTP_ICE_adme_parameters
1unitlessGHS ClassificationDermalGuinea pigNTP_ICE_skin_sensitization
4unitlessGHS ClassificationInhalation-NTP_ICE_acute_inhalation
=3UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=3UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=4UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=4UnitlessGHS classificationoralRat (Male)NTP_ICE_acute_oral
5unitlessGHS classificationDermalRatNTP_ICE_acute_dermal
=5UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
5840nMIC25--NTP_ICE_endocrine
range0.53mg/LLC50Inhalation-NTP_ICE_acute_inhalation
0.7mg/LLC50Inhalation-NTP_ICE_acute_inhalation
0.785mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>2.04mg/LLC50Inhalation-NTP_ICE_acute_inhalation
4.35mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=150mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=196mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=249mg/kg bwLD50oralRat (Male/Female)NTP_ICE_acute_oral
=322mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=1750mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
>2000mg/kgLD50DermalRatNTP_ICE_acute_dermal
>5000mg/kgLD50DermalRatNTP_ICE_acute_dermal
>5000mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
>1.134mg/kg bw/dayLELoralDogToxValDB_ToxRefDB

Showing 50 of 100 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DELTAMETHRIN
ChEMBL Phase
-1
Adverse Events
25
Bioactivity
1
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Deltamethrin?

Deltamethrin (CAS 52918-63-5) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H331; H301; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Deltamethrin?

Deltamethrin has 100 NOAEL studies in the database. The lowest reported value is 0.005 ml/kg via dermal in Rat. Source: ToxValDB_ECOTOX.

What regulatory lists include Deltamethrin?

Deltamethrin appears on 8 regulatory/inventory lists including active_ingredient; agricultural; applied; Pesticides, active_ingredient; Europe; Pesticides, agricultural; detected; fruits_and_vegetables; Pesticides; residue, and 5 more. Source: EPA CPDat.

Is Deltamethrin a carcinogen according to IARC?

Deltamethrin is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1990). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Deltamethrin used in cosmetics?

Yes, Deltamethrin is also indexed as a cosmetic ingredient under the name Deltamethrin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Deltamethrin come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Deltamethrin have different safety status in cosmetics vs industrial chemicals?

Deltamethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H301, H400, H410).

Is Deltamethrin used outside industrial chemicals?

Deltamethrin also appears in cosmetics, pharmaceutical, cannabis databases.