Is Delta-Hexalactone safe in cosmetics?
Delta-Hexalactone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Delta-Hexalactone
INCI: DELTA-HEXALACTONE
Delta-Hexalactone (CAS 823-22-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with coumarinic, coconut, and cream notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 823-22-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with coumarinic, coconut, and cream notes
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
6-methyloxan-2-one
InChIKey
RZTOWFMDBDPERY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 3167
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Delta-Hexalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
224
Source: WHO/JECFA
JECFA Evaluation
5-HYDROXYHEXANOIC ACID LACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
JECFA Evaluation
delta-HEXALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Delta-Hexalactone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Delta-Hexalactone allowed in the EU?
Delta-Hexalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Hexalactone do in cosmetics?
Delta-Hexalactone functions as: Fragrance ingredient with coumarinic, coconut, and cream notes. It is classified as a cosmetic ingredient in our database. CAS number: 823-22-3.
Is Delta-Hexalactone used outside cosmetics?
Delta-Hexalactone also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Delta-Hexalactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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