What is the NOAEL for 6-Methyloxan-2-one?
6-Methyloxan-2-one has 9 NOAEL studies in the database. The lowest reported value is 5 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
6-Methyloxan-2-one
CAS 823-22-3
6-Methyloxan-2-one (CAS 823-22-3) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
6-Methyloxan-2-one
CAS Number
823-22-3
DTXSID
DTXSID30862431
Molecular Formula
C6H10O2
InChI Key
RZTOWFMDBDPERY-UHFFFAOYSA-N
Monoisotopic Mass
114.06808
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| C8456O4551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C8456O4551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C8456O4551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C8456O4551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 3375 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 9 of 9 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 6-Methyloxan-2-one?
6-Methyloxan-2-one appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 6-Methyloxan-2-one used in cosmetics?
Yes, 6-Methyloxan-2-one is also indexed as a cosmetic ingredient under the name Delta-Hexalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 6-Methyloxan-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 6-Methyloxan-2-one used outside industrial chemicals?
6-Methyloxan-2-one also appears in cosmetics databases.