Is Cysteamine HCl safe in cosmetics?
Cysteamine HCl has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Cysteamine HCl
Also known as: Ethanethiol, 2-amino-, hydrochloride, Ethanethiol, 2-amino-, hydrochloride (1:1), Mercaptamine hydrochloride, 1-Aminoethane-2-thiol hydrochloride, Bekaptan (+8 more)
INCI: CYSTEAMINE HCL
Cysteamine HCl (CAS 156-57-0) is a cosmetic cosmetic ingredient functioning as Skin Brightening. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 156-57-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Brightening
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
205-858-1
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Status permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cysteamine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 5 | Hair waving/straightening products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
depigmentation
{"cas_number": "156-57-0", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Synthetic or isolated bioactive with melanin reduction properties", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Hair waving or straightening
Reducing agent
Expert Verdict
Expert safety assessment and concern-level summary for Cysteamine HCl.
Regulatory Flags
EU Restricted
Known Synonyms
Ethanethiol, 2-amino-, hydrochloride
Ethanethiol, 2-amino-, hydrochloride (1:1)
Mercaptamine hydrochloride
1-Aminoethane-2-thiol hydrochloride
Bekaptan
EINECS 205-858-1
Ethylamine, 2-mercapto-, hydrochloride
Mercaptoethylamine hydrochloride
NSC 21116
eta-Mercaptoethylamine hydrochloride
beta-Mercaptoaethylamin chlorhydrat
Cysteaminhydrochlorid
UNII-IF1B771SVB
Chemical Function
Antioxidant
Reducing agent
Hair waving or straightening
Regulatory Lists
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CYSTEAMINE HYDROCHLORIDE
ChEMBL ID
CHEMBL1256137
Max Phase
4
Adverse Event Associations
22
Frequently Asked Questions
Is Cysteamine HCl allowed in the EU?
Cysteamine HCl EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cysteamine HCl do in cosmetics?
Cysteamine HCl functions as: Skin Brightening. It is classified as a cosmetic ingredient in our database. CAS number: 156-57-0.
Is Cysteamine HCl used outside cosmetics?
Cysteamine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cysteamine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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