Is Crotamiton safe in cosmetics?
Crotamiton has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Crotamiton
Also known as: N-Ethyl-N-(2-methylphenyl)but-2-enamide (Crotamiton), 3-12-00-01856, BRN 3275497, Caswell No. 431B, EINECS 207-596-3 (+6 more)
INCI: CROTAMITON
Crotamiton (CAS 483-63-6) is a cosmetic cosmetic ingredient functioning as Anti-pruritic agent, antimicrobial (primarily pharmaceutical — used as. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 483-63-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Crotamiton is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Anti-pruritic agent, antimicrobial (primarily pharmaceutical — used as scabicide in OTC drugs)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
N-ethyl-N-(2-methylphenyl)but-2-enamide
InChIKey
DNTGGZPQPQTDQF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
FDA: Regulated as OTC drug active ingredient (anti-scabies); use in cosmetics would likely trigger drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Crotamiton.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Crotamiton.
Regulatory Flags
potential-allergen
Known Synonyms
N-Ethyl-N-(2-methylphenyl)but-2-enamide (Crotamiton)
3-12-00-01856
BRN 3275497
Caswell No. 431B
EINECS 207-596-3
EPA Pesticide Chemical Code 055701
Eurasil
Crotamitonum
Bestloid
UNII-D6S4O4XD0H
crotonyl-N-ethyl-o-toluidine
Chemical Function
Solvent
Biocide
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183440
Adverse Event Associations
146
Frequently Asked Questions
Is Crotamiton allowed in the EU?
Crotamiton EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Crotamiton do in cosmetics?
Crotamiton functions as: Anti-pruritic agent, antimicrobial (primarily pharmaceutical — used as scabicide in OTC drugs). It is classified as a cosmetic ingredient in our database. CAS number: 483-63-6.
Is Crotamiton used outside cosmetics?
Crotamiton also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Crotamiton have different safety status in cosmetics vs industrial chemicals?
Crotamiton is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319).
Compliance Tools
Check Crotamiton compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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