What is the NOAEL for Crotamiton?
Crotamiton has 6 NOAEL studies in the database. The lowest reported value is D6S4O4XD0H UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Crotamiton
Also known as: N-Ethyl-N-(2-methylphenyl)but-2-enamide (Crotamiton), 3-12-00-01856, BRN 3275497, Caswell No. 431B, EINECS 207-596-3 (+6 more)
CAS 483-63-6
Crotamiton (CAS 483-63-6) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Crotamiton is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Crotamiton
CAS Number
483-63-6
DTXSID
DTXSID6040664
Molecular Formula
C13H17NO
InChI Key
DNTGGZPQPQTDQF-UHFFFAOYSA-N
Monoisotopic Mass
203.131014
Synonyms
N-Ethyl-N-(2-methylphenyl)but-2-enamide (Crotamiton)3-12-00-01856BRN 3275497Caswell No. 431BEINECS 207-596-3EPA Pesticide Chemical Code 055701EurasilCrotamitonumBestloidUNII-D6S4O4XD0Hcrotonyl-N-ethyl-o-toluidine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
SolventBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| D6S4O4XD0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D6S4O4XD0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D6S4O4XD0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D6S4O4XD0H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =12 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| =60 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 6 of 6 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183440
ChEMBL Phase
Not listed
Adverse Events
146
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Crotamiton?
Crotamiton appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Crotamiton used in cosmetics?
Yes, Crotamiton is also indexed as a cosmetic ingredient under the name Crotamiton. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Crotamiton come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Crotamiton have different safety status in cosmetics vs industrial chemicals?
Crotamiton is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319).
Is Crotamiton used outside industrial chemicals?
Crotamiton also appears in cosmetics, pharmaceutical databases.