Is cis-3-Hexenyl Isobutyrate safe in cosmetics?
cis-3-Hexenyl Isobutyrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
cis-3-Hexenyl Isobutyrate
Also known as: EINECS 255-424-0, beta,gamma-Hexenyl isobutanoate, (Z)-2-Methylpropanoic acid 3-hexenyl ester, (Z)-3-Hexenyl isobutyrate, UNII-R84N0RD251
INCI: CIS-3-HEXENYL ISOBUTYRATE
cis-3-Hexenyl Isobutyrate (CAS 41519-23-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with fruity, green, and apple-like notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 41519-23-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with fruity, green, and apple-like notes
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] 2-methylpropanoate
InChIKey
OSMAJVWUIUORGC-WAYWQWQTSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
RIFM safety assessed and cleared across all 7 endpoints; Cramer Class I
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1275
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXENYL ISOBUTYRATE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/101 | FAS 42-JECFA 51/267 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Isobutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 255-424-0
beta,gamma-Hexenyl isobutanoate
(Z)-2-Methylpropanoic acid 3-hexenyl ester
(Z)-3-Hexenyl isobutyrate
UNII-R84N0RD251
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183445
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
(Z)-3-HEXENYL ISOBUTYRATE
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl Isobutyrate allowed in the EU?
cis-3-Hexenyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Isobutyrate do in cosmetics?
cis-3-Hexenyl Isobutyrate functions as: Fragrance ingredient with fruity, green, and apple-like notes. It is classified as a cosmetic ingredient in our database. CAS number: 41519-23-7.
Is cis-3-Hexenyl Isobutyrate used outside cosmetics?
cis-3-Hexenyl Isobutyrate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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