What is the NOAEL for (3Z)-Hex-3-en-1-yl 2-methylpropanoate?
(3Z)-Hex-3-en-1-yl 2-methylpropanoate has 11 NOAEL studies in the database. The lowest reported value is R84N0RD251 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(3Z)-Hex-3-en-1-yl 2-methylpropanoate
Also known as: EINECS 255-424-0, beta,gamma-Hexenyl isobutanoate, cis-3-Hexenyl isobutyrate, (Z)-2-Methylpropanoic acid 3-hexenyl ester, (Z)-3-Hexenyl isobutyrate (+1 more)
CAS 41519-23-7
(3Z)-Hex-3-en-1-yl 2-methylpropanoate (CAS 41519-23-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for cis-3-Hexenyl Isobutyrate →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
(3Z)-Hex-3-en-1-yl 2-methylpropanoate
CAS Number
41519-23-7
DTXSID
DTXSID0047585
Molecular Formula
C10H18O2
InChI Key
OSMAJVWUIUORGC-WAYWQWQTSA-N
Monoisotopic Mass
170.13068
Synonyms
EINECS 255-424-0beta,gamma-Hexenyl isobutanoatecis-3-Hexenyl isobutyrate(Z)-2-Methylpropanoic acid 3-hexenyl ester(Z)-3-Hexenyl isobutyrateUNII-R84N0RD251
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| R84N0RD251 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R84N0RD251 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R84N0RD251 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R84N0RD251 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =127 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =127 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (Z)-hex-3-enyl isobutyrate | 255-424-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183445
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (3Z)-Hex-3-en-1-yl 2-methylpropanoate?
(3Z)-Hex-3-en-1-yl 2-methylpropanoate appears on 4 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency, consumer_product, and 1 more. Source: EPA CPDat.
Is (3Z)-Hex-3-en-1-yl 2-methylpropanoate used in cosmetics?
Yes, (3Z)-Hex-3-en-1-yl 2-methylpropanoate is also indexed as a cosmetic ingredient under the name cis-3-Hexenyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (3Z)-Hex-3-en-1-yl 2-methylpropanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (3Z)-Hex-3-en-1-yl 2-methylpropanoate used outside industrial chemicals?
(3Z)-Hex-3-en-1-yl 2-methylpropanoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.