Is Cis-3-Hexenol safe in cosmetics?
Cis-3-Hexenol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Cis-3-Hexenol
Also known as: cis-3-hexen-1-ol, 4-01-00-02141, BRN 1719712, EINECS 213-192-8, FEMA No. 2563 (+6 more)
INCI: 3-HEXENOL
Cis-3-Hexenol (CAS 928-96-1) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 127 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 928-96-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(Z)-hex-3-en-1-ol
InChIKey
UFLHIIWVXFIJGU-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS No. 2563; approved for food use under 21 CFR 172.515; no cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cis-3-Hexenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Cis-3-Hexenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cis-3-Hexenol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (6)
JECFA Number
315
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(3E)-HEXENOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXEN-1-OL | 2023 | Not considered | JECFA requests that updated exposure data (including both MSDI and SPET values) be provided for the flavouring agents cis-3-hexen-1-ol (No. 315), 10-undecenal (No. 330), 10-undecenoic acid (No. 331), cis-3-hexenyl cis3-hexenoate (No. 336), 5-hexenol (No. 1623) and methyl 10-undecenoate (No. 1639) within 2 years (i.e. by December 2025) so that a re-evaluat
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
GREEN LEAF ALCOHOL | 2023 | Not considered | JECFA requests that updated exposure data (including both MSDI and SPET values) be provided for the flavouring agents cis-3-hexen-1-ol (No. 315), 10-undecenal (No. 330), 10-undecenoic acid (No. 331), cis-3-hexenyl cis3-hexenoate (No. 336), 5-hexenol (No. 1623) and methyl 10-undecenoate (No. 1639) within 2 years (i.e. by December 2025) so that a re-evalu
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(E)-3-HEXENOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Solvent
Viscosity modifier
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cis-3-Hexenol.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cis-3-Hexenol by CAS number or substance name.
Studies
2
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
cis-3-hexen-1-ol
4-01-00-02141
BRN 1719712
EINECS 213-192-8
FEMA No. 2563
beta-gamma-Hexenol
Z-3-Hexenol
NSC 74451
UNII-V14F8G75P4
(3Z)-hex-3-en-1-ol
Blatteralkohol
Chemical Function
Fragrance
Deodorizer
Softener and conditioner
Solvent
Humectant
Viscosity modifier
Flavouring and nutrient
Regulatory Lists
inert_ingredient; Pesticides
air; Cleaning products and household care - air freshener; detected; emissions
inert_ingredient; non_food_use; Pesticides
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
SCIL (9/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CIS-3-HEXENOL
ChEMBL ID
CHEMBL2251452
Frequently Asked Questions
Is Cis-3-Hexenol allowed in the EU?
Cis-3-Hexenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cis-3-Hexenol do in cosmetics?
Cis-3-Hexenol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 928-96-1.
What is the NOAEL for Cis-3-Hexenol?
The NOAEL (No Observed Adverse Effect Level) for Cis-3-Hexenol is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Cis-3-Hexenol used outside cosmetics?
Cis-3-Hexenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cis-3-Hexenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Benzyl Acetate
Excellent
Same category
Perfuming, Masking, Solvent
Methyl Dihydrojasmonate
Excellent
Same category
Fragrance, Perfuming, Masking Agent
Ethyl Linalool
Good
Same category
Fragrance with soft floral-fresh note...
Ethyl Vanillin
Good
Same category
Fragrance (perfuming agent); 3-4x str...
Geranyl Acetate
Good
Same category
Fragrance
Indole
Good
Same category
Fragrance (perfuming agent); floral n...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3-Hexenol
Good
Chemical family
Fragrance, Skin Conditioning
Glycol Dioleate
Good
Chemical family
Skin-conditioning agent — emollient
Methylheptanone
Moderate
Chemical family
Fragrance ingredient
Is Cis-3-Hexenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cis-3-Hexenol in your formulation.