NOAEL Studies
Cosmetic Ingredient
Cis-3-Hexenol NOAEL Studies
INCI: 3-HEXENOL
CAS: 928-96-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =127 | mg/kg bw/day | Rat | oral: drinking water | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2864 - other - systemic - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =127 | mg/kg bw/day | Rat | oral: drinking water | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2864 - other - systemic - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559 |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11527; row=10116; data_type=In Vivo; mixture=Chemical; chemical_name=(Z)-3-Hexen-1-ol; preferred_name=(Z)-3-Hexen-1-ol; dtxsid=DTXSID6022137; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022137; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=226; RecordID=ARPathway2016_1721; DatasetName=ARPathway2016; DTXSID=DTXSID6022137; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022137 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11071; Record_ID=skin_sensitization_invivo_2420; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022137; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90179-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022137 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11069; Record_ID=skin_sensitization_invivo_2420; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022137; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90179-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022137 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11075; Record_ID=skin_sensitization_invivo_2420; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022137; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90179-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022137 |
ToxValDB_ECHA_IUCLID 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfc8d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12217/7/9/3?documentUUID=d72d9a24-f8de-4a16-ac32-634c7dd68a59; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=ECHA IUCLID:15825299:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82438023fcf3749b188945ddc977f572 |
| ToxValDB_ECHA_IUCLID | NOEL | =278.75 | mg/kg bw/day | Rat | oral | chronic; 98 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf70e4b0a7c65d1cdf0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12217/7/6/2?documentUUID=d72d9a24-f8de-4a16-ac32-634c7dd68a59; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=ECHA IUCLID:15850001:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4662304edc66fe2cdbb81ab13fa79456 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =127 | mg/kg bw/day | Rat | oral | chronic; 98 days | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4559.; TITLE=Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4559; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15624817:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fc01a6f86385891dad17741d5a90b67 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =11.75 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632548:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64006a9f93f06f386decb9c11dd3c512 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | V14F8G75P4 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V14F8G75P4"} |
| openFDA substances | FDA UNII substance identifier | V14F8G75P4 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V14F8G75P4"} |
| openFDA substances | FDA UNII substance identifier | V14F8G75P4 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V14F8G75P4"} |
| openFDA substances | FDA UNII substance identifier | V14F8G75P4 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V14F8G75P4"} |