Excellent Cosmetic Ingredient NOAEL Data GHS Classified SCCS/CIR Reviewed

CI 77120 (Barium Sulfate)

Also known as: E-Z Preparations, Artificial barite, Artificial heavy spar, Baraflave, Baricon (+15 more)

INCI: CI 77120

CI 77120 (Barium Sulfate) (CAS 7727-43-7) is a cosmetic cosmetic ingredient functioning as Colorant; Opacifying Agent. Inorganic insoluble salt of barium and sulfate. Reported NOAEL =179.5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 7727-43-7 →

Auto-generated CPSR Part A draft with source citations
Function
Colorant; Opacifying Agent. Inorganic insoluble salt of barium and sulfate (BaSO4). Functions as a white opacifier and extender in cosmetic formulations, imparting opacity and a smooth texture. Used in face powders, foundations, blushes, and eye shadows. CIR Expert Panel completed a final safety assessment concluding Barium Sulfate is safe as used in cosmetics when meeting purity requirements. Distinct from soluble barium salts, which are toxic; the insolubility of BaSO4 is the primary basis for its safety.
Safety Rating
EXCELLENT

Chemistry & Identifiers

Formula
BaO4S
MW
233.39 g/mol
EC Number
231-784-4
PubChem CID
24414
IUPAC Name
barium(2+) sulfate
InChIKey
TZCXTZWJZNENPQ-UHFFFAOYSA-L

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Listed as a color additive exempt from certification under 21 CFR 73.2120 (Subpart C, Cosmetics). Barium Sulfate may be safely used in coloring cosmetics generally, including those intended for use in the area of the eye, in amounts consistent with good manufacturing practice.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77120 (Barium Sulfate).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for CI 77120 (Barium Sulfate). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =179.5 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID
NOAEL =201.5 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Long-term Exposure Effects
Repeated or prolonged inhalation of dust particles may cause effects on the lungs. This may result in baritosis (a form of benign pneumoconiosis).
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe

lfate should be formulated to be non- irritating. The Panel concluded that barium sulfate is safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be nonirritating. Keywords barium sulfate, safety, cosmetics Introduction The saf

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex IV — Permitted Colorants
Product type: White

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (2)
Jurisdiction Status Max % Product Type
BR permitted_colorant - Column 1: All products
ASEAN permitted_colorant - All products

Additional Ingredient Properties

1 property record from structured ingredient metadata.

colorant
{"Common_Name": "Barium Sulfate", "Chemical_Name": "Barium sulfate", "CAS_Number": "7727-43-7", "Colorant_Type": "Inorganic Filler", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "White extender"}

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0827
Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive Binder Conductive agent Dye Filler Flame retardant Opacifer Pigment Processing aids not otherwise specified pH regulating agent
Regulatory List Membership (3)
EU Regulated in Personal Care FDA Indirect Food Contact Additives EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for CI 77120 (Barium Sulfate).

Regulatory Flags

inorganic-colorant mineral-pigment eu-annex-iv eu-unrestricted fda-exempt-certification eye-area-permitted opacifier insoluble-salt cir-reviewed eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to CI 77120 (Barium Sulfate) by CAS number or substance name.

Studies
2
Lowest NOAEL
179.5 mg/kg bw/day
Highest NOAEL
201.5 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

E-Z Preparations Artificial barite Artificial heavy spar Baraflave Baricon Barii sulphas Baritop 100 Baritop G Powder Barium Andreu Barium sulfuricum Barobag Barocat Barodense Baroloid Barosperse 110 Barosperse II Bar-Test Barytes Barytgen Baryx Colloidal

Chemical Function

Dye Opacifer Pigment Filler

Regulatory Lists

inert_ingredient; non_food_use; Pesticides Indirect additives food contact (10/2018) Europe; plastic_additive Europe; Personal care Canada; pharmaceutical inert_ingredient; Pesticides Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe drinking_water; Europe; manufacturing; plastic_additive

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
BARIUM SULFATE
ChEMBL ID
CHEMBL2105897
Max Phase
4
Adverse Event Associations
49
View full pharmaceutical profile →

Frequently Asked Questions

Is CI 77120 (Barium Sulfate) safe in cosmetics?

CI 77120 (Barium Sulfate) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is CI 77120 (Barium Sulfate) allowed in the EU?

CI 77120 (Barium Sulfate) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 77120 (Barium Sulfate) do in cosmetics?

CI 77120 (Barium Sulfate) functions as: Colorant; Opacifying Agent. Inorganic insoluble salt of barium and sulfate (BaSO4). Functions as a white opacifier and extender in cosmetic formulations, imparting opacity and a smooth texture. Used in face powders, foundations, blushes, and eye shadows. CIR Expert Panel completed a final safety assessment concluding Barium Sulfate is safe as used in cosmetics when meeting purity requirements. Distinct from soluble barium salts, which are toxic; the insolubility of BaSO4 is the primary basis for its safety.. It is classified as a cosmetic ingredient in our database. CAS number: 7727-43-7.

What is the NOAEL for CI 77120 (Barium Sulfate)?

The NOAEL (No Observed Adverse Effect Level) for CI 77120 (Barium Sulfate) is =179.5 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is CI 77120 (Barium Sulfate) used outside cosmetics?

CI 77120 (Barium Sulfate) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does CI 77120 (Barium Sulfate) have different safety status in cosmetics vs industrial chemicals?

CI 77120 (Barium Sulfate) is classified GHS Danger (H302, H332, H372, H402, H412) in the chemicals database but is allowed in EU cosmetics.

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