What is the NOAEL for Barium sulfate?
Barium sulfate has 13 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Barium sulfate
Also known as: E-Z Preparations, Artificial barite, Artificial heavy spar, Baraflave, Baricon (+15 more)
CAS 7727-43-7
Barium sulfate (CAS 7727-43-7) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Barium sulfate is classified GHS Danger (H302, H332, H372, H402, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Barium sulfate
CAS Number
7727-43-7
DTXSID
DTXSID0050471
Molecular Formula
Ba.H2O4S
InChI Key
TZCXTZWJZNENPQ-UHFFFAOYSA-L
Monoisotopic Mass
235.872627
Synonyms
E-Z PreparationsArtificial bariteArtificial heavy sparBaraflaveBariconBarii sulphasBaritop 100Baritop G PowderBarium AndreuBarium sulfuricumBarobagBarocat
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Long-term Effects | Repeated or prolonged inhalation of dust particles may cause effects on the lungs. This may result in baritosis (a form of benign pneumoconiosis). |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| NIOSH | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DyeOpaciferPigmentFillerBinderProcessing aids not otherwise specifiedFlame retardantAnti-adhesive/cohesiveConductive agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 25BB7EKE2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25BB7EKE2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25BB7EKE2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25BB7EKE2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =40 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=250 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| <=300 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/m3 | NEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =179.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =201.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2000 | ppm | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =4000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Barium sulfate | 231-784-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BARIUM SULFATE
ChEMBL Phase
4
Adverse Events
49
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Barium sulfate?
Barium sulfate appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), Europe; plastic_additive, and 5 more. Source: EPA CPDat.
What are the occupational exposure limits for Barium sulfate?
Occupational exposure limits for Barium sulfate are set by OSHA, NIOSH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Barium sulfate used in cosmetics?
Yes, Barium sulfate is also indexed as a cosmetic ingredient under the name Barium Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Barium sulfate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Barium sulfate have different safety status in cosmetics vs industrial chemicals?
Barium sulfate is classified GHS Danger (H302, H332, H372, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Is Barium sulfate used outside industrial chemicals?
Barium sulfate also appears in cosmetics, pharmaceutical databases.