Also known as: C.I. Acid Yellow 4, C.I. Acid Yellow 3, D & C Yellow No. 10, Food Yellow 13, Japan Yellow 203 (+12 more)
INCI: CI 47005
D&C Yellow No. 10 (Quinoline Yellow) (CAS 8004-92-0) is a cosmetic colorant functioning as Colorant, Hair Dyeing Agent. NOAEL 875 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 0.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 8004-92-0 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for D&C Yellow No. 10 (Quinoline Yellow).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for D&C Yellow No. 10 (Quinoline Yellow). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0783 mg/kg bw | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.0783 mg/kg bw | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.0783 mg/kg bw | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.0783 mg/kg bw | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =250 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =250 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for D&C Yellow No. 10 (Quinoline Yellow) across SCCS product categories, with measured dermal absorption where available.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_colorant | - | Column 3: Not near mucous membranes |
| ASEAN | permitted_colorant | - | Not eye area (0.5% limit in non-oxidative hair dye — Annex III since 2024) |
| MY | restricted | 0.5% in non-oxidative hair dye | Non-oxidative hair dye products |
| PH | restricted | 0.5% non-oxidative hair dye | Non-oxidative hair dye products |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 96.71% | - | - | SCCS/0253 |
| measured | 82.96% | - | - | SCCS/0253 |
| measured | 91.95% | - | - | SCCS/0253 |
| measured | 0.19% | - | - | SCCS/0253 |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for D&C Yellow No. 10 (Quinoline Yellow).
Public NOAEL study rows linked to D&C Yellow No. 10 (Quinoline Yellow) by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 96.71% | - | - |
| 82.96% | - | - |
| 91.95% | - | - |
| 0.19% | - | - |
D&C Yellow No. 10 (Quinoline Yellow) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
D&C Yellow No. 10 (Quinoline Yellow) EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
D&C Yellow No. 10 (Quinoline Yellow) functions as: Colorant, Hair Dyeing Agent. It is classified as a Colorant in our database. CAS number: 8004-92-0.
The NOAEL (No Observed Adverse Effect Level) for D&C Yellow No. 10 (Quinoline Yellow) is =0.0783 mg/kg bw based on a reproductive toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
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